| UniProt/SwissProt ID: | PROS_HUMAN |
| Description: | protein S (alpha) [Source:HGNC Symbol;Acc:9456] |
| Location: | chr3 q11.1 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y259 | QLCVNyPGGYT | PhosphoSitePlus | |
| S122 | IPDQCsPLPCN | EGF | PhosphoSitePlus |
| T104 | AARQStNAYPD | PhosphoSitePlus | |
| Y266 | GGYTCyCDGKK | PhosphoSitePlus | |
| Dephosphorylation site |
| PROS_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000377783 | E545G | BIOMART, HPI | Colorectal Cancer | 21930507, 21930502, 16959974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000377783 | Ovarian Cancer | Normal vs. Cancer | tissue | Up | 2.3 | 20162585 |
| Hyperphosphorylation site |
| PROS_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PROS_HUMAN | UFO_HUMAN | ligand -> receptor | HPMR |
| PROS_HUMAN | TYRO3_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04610 | Complement and coagulation cascades |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0002576 | platelet degranulation | TAS | biological_process |
| GO:0005576 | extracellular region | NAS | cellular_component |
| GO:0005789 | endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0004866 | endopeptidase inhibitor activity | TAS | molecular_function |
| GO:0043687 | post-translational protein modification | TAS | biological_process |
| GO:0044267 | cellular protein metabolic process | TAS | biological_process |
| GO:0042730 | fibrinolysis | IEA | biological_process |
| GO:0031093 | platelet alpha granule lumen | TAS | cellular_component |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0017187 | peptidyl-glutamic acid carboxylation | TAS | biological_process |
| GO:0030449 | regulation of complement activation | TAS | biological_process |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0006508 | proteolysis | TAS | biological_process |
| GO:0050900 | leukocyte migration | TAS | biological_process |
| GO:0010951 | negative regulation of endopeptidase activity | TAS | biological_process |