Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PQBP1_HUMAN
Description:polyglutamine binding protein 1 [Source:HGNC Symbol;Acc:9330]
Location:chrX p11.23
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y33IIAEDyDDDPVPhosphoSitePlus
S152QRPYPsPGAVLHPRD
S94AKKLRsSNADAPhosphoSitePlus; HPRD
S210DPSSYsDAPRGPhosphoSitePlus
Y209MDPSSySDAPRPhosphoSitePlus
Y150FQQRPyPSPGAHPRD
Y146DRERGyDKVDRPhosphoSitePlus
Y245FQQRPyPSPGAHPRD; phosphoELM
S247QRPYPsPGAVLPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
PQBP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000365747R224WHPIColorectal Cancer16959974
ENSP00000391759R224WHPIColorectal Cancer16959974
ENSP00000379985R224WHPIColorectal Cancer16959974
ENSP00000218224D129GCOSMICOvarian Cancer21720365
ENSP00000365747D129GCOSMICOvarian Cancer21720365
ENSP00000379985D129GCOSMICOvarian Cancer21720365
ENSP00000365747R224WSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000391759R224WCOSMICIntestines Cancer16959974
ENSP00000218224R224WSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000379985R224WSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000391759D129GCOSMICOvarian Cancer21720365

Differential expressed protein
PQBP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PQBP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ARBK1_HUMANPQBP1_HUMANkinase -> substrateRobert H Newman (2013)
GRK5_HUMANPQBP1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PQBP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0003713transcription coactivator activityTASmolecular_function
GO:0034063stress granule assemblyIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0071598neuronal ribonucleoprotein granuleIEAcellular_component
GO:0003677DNA bindingTASmolecular_function
GO:0010494cytoplasmic stress granuleIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005634nucleusIDAcellular_component


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