Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLCB4_HUMAN
Description:phospholipase C, beta 4 [Source:HGNC Symbol;Acc:9059]
Location:chr20 p12.3
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1021IVAQHtKEWSEPhosphoSitePlus
Y623QMSRIyPKGGRHPRD
Y721KKIGTyVEVDMC2PhosphoSitePlus
S890VTPQSsSELRPPhosphoSitePlus; HPRD; phosphoELM
S867IADVPsDTSKNPhosphoSitePlus
T886AKANVtPQSSSPhosphoSitePlus
T1004EIKIQtLTSDHPhosphoSitePlus
T998EMKKEtEIKIQPhosphoSitePlus
S620NKRQMsRIYPKHPRD

Dephosphorylation site
PLCB4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000334105T898MBIOMARTBreast Cancer21930507, 21930502
ENSP00000367762P165LCOSMICMelanoma21499247
ENSP00000367762R254QCOSMICPancreatic Cancer
ENSP00000334105S342LCOSMICMelanoma21499247
ENSP00000278655K933NBIOMARTBreast Cancer21930507, 21930502
ENSP00000367762H1159NCOSMICHead and Neck Cancer21798893
ENSP00000334105R760WCOSMICMelanoma21499247
ENSP00000334105E737KCOSMICMelanoma21499247
ENSP00000367762D496NCOSMICMelanoma21499247
ENSP00000278655T898MBIOMARTBreast Cancer21930507, 21930502
ENSP00000367762E1086KCOSMICMelanoma21499247
ENSP00000334105N1192HBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000334105L83PCOSMICMelanoma21499247
ENSP00000367754T898MBIOMARTBreast Cancer21930507, 21930502
ENSP00000334105G95WCOSMICSkin Cancer21984974
ENSP00000334105E1086KCOSMICMelanoma21499247
ENSP00000334105K933NBIOMARTBreast Cancer21930507, 21930502
ENSP00000367762S342LCOSMICMelanoma21499247
ENSP00000367762M1ITCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000367762R760WCOSMICMelanoma21499247
ENSP00000334105M1ITCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000367762K933NBIOMARTBreast Cancer21930507, 21930502
ENSP00000334105D496NCOSMICMelanoma21499247
ENSP00000367762T898MBIOMARTBreast Cancer21930507, 21930502
ENSP00000367754K933NBIOMARTBreast Cancer21930507, 21930502
ENSP00000367762L83PCOSMICMelanoma21499247
ENSP00000334105P165LCOSMICMelanoma21499247
ENSP00000334105R251QCOSMICMelanoma21499247
ENSP00000334105R254QCOSMICPancreatic Cancer
ENSP00000334105H1159NCOSMICHead and Neck Cancer21798893
ENSP00000367762R251QCOSMICMelanoma21499247
ENSP00000367762G95WCOSMICSkin Cancer21984974
ENSP00000367762E737KCOSMICMelanoma21499247

Differential expressed protein
PLCB4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PLCB4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNAQ_HUMANPLCB4_HUMANGprotein -> effectorgpDB
GNA11_HUMANPLCB4_HUMANGprotein -> effectorgpDB
GNA15_HUMANPLCB4_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04723Retrograde endocannabinoid signaling
hsa01100Metabolic pathways
hsa04728Dopaminergic synapse
hsa04720Long-term potentiation
hsa04961Endocrine and other factor-regulated calcium reabs
hsa05010Alzheimer's disease
hsa00562Inositol phosphate metabolism
hsa04726Serotonergic synapse
hsa04916Melanogenesis
hsa05146Amoebiasis
hsa04725Cholinergic synapse
hsa04971Gastric acid secretion
hsa05016Huntington's disease
hsa04062Chemokine signaling pathway
hsa04730Long-term depression
hsa04310Wnt signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04020Calcium signaling pathway
hsa04724Glutamatergic synapse
hsa04970Salivary secretion
hsa05143African trypanosomiasis
hsa04972Pancreatic secretion
hsa05142Chagas disease (American trypanosomiasis)
hsa04912GnRH signaling pathway
hsa04540Gap junction
hsa04270Vascular smooth muscle contraction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004435phosphatidylinositol phospholipase C activityIEAmolecular_function
GO:0004871signal transducer activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0016042lipid catabolic processIEAbiological_process
GO:0008081phosphoric diester hydrolase activityIEAmolecular_function
GO:0004629phospholipase C activityTASmolecular_function
GO:0014069postsynaptic densityIEAcellular_component
GO:0005790smooth endoplasmic reticulumIEAcellular_component
GO:0030425dendriteIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0006629lipid metabolic processIEAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0007165signal transductionIEAbiological_process


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