| UniProt/SwissProt ID: | PF2R_HUMAN |
| Description: | prostaglandin F receptor (FP) [Source:HGNC Symbol;Acc:9600] |
| Location: | chr1 p31.1 |
| Node attribute: | GPCR; receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y177 | LGHRDyKIQAS | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| PF2R_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000359793 | H278L | BIOMART | Neoplasms by Histologic Type | 21930507, 21930502 | ENSP00000359794 | A253V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000359792 | S2F | COSMIC | Breast Cancer | 20668451 | ENSP00000359793 | L203P | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000359794 | H143N | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000359792 | L296F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000359794 | G273* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000359793 | A253V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000359794 | H143N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000359794 | S29F | COSMIC | Melanoma | 21499247 | ENSP00000359792 | S94F | COSMIC | Breast Cancer | 20668451 | ENSP00000359792 | A253V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000359794 | A253V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000359794 | S94F | COSMIC | Breast Cancer | 20668451 | ENSP00000359793 | G273* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000359794 | L203P | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000359794 | S2F | COSMIC | Breast Cancer | 20668451 | ENSP00000359793 | H143N | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000359794 | G273* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000359792 | S29F | COSMIC | Melanoma | 21499247 | ENSP00000359794 | H278L | COSMIC | Central Nervous System Neoplasms | ENSP00000359792 | L203P | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000359792 | H143N | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000359793 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 21 hour) | cell line | Down | 0.53 | 15169874 |
| Hyperphosphorylation site |
| PF2R_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PGH2_HUMAN | PF2R_HUMAN | ligand -> receptor | HPMR |
| PF2R_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| PF2R_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| GLHA_HUMAN | PF2R_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04020 | Calcium signaling pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005576 | extracellular region | IDA | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0004958 | prostaglandin F receptor activity | IEA | molecular_function |
| GO:0043066 | negative regulation of apoptotic process | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0007567 | parturition | TAS | biological_process |
| GO:0032496 | response to lipopolysaccharide | IEA | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |