| UniProt/SwissProt ID: | PD2R_HUMAN |
| Description: | prostaglandin D2 receptor (DP) [Source:HGNC Symbol;Acc:9591] |
| Location: | chr14 q22.1 |
| Node attribute: | GPCR; receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S254 | DGREAsPQPLE | 7tm_1 | PhosphoSitePlus |
| S352 | SRCSNsTNMES | PhosphoSitePlus | |
| S358 | TNMESsL____ | PhosphoSitePlus | |
| S357 | STNMEsSL___ | PhosphoSitePlus | |
| T353 | RCSNStNMESS | PhosphoSitePlus | |
| Dephosphorylation site |
| PD2R_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000303424 | Y226H | COSMIC | Lung Cancer | 20668451 | ENSP00000303424 | W131L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000303424 | S119W | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000303424 | W131L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000303424 | E190K | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| PD2R_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PD2R_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| HPGDS_HUMAN | PD2R_HUMAN | ligand -> receptor | HPMR |
| PD2R_HUMAN | GNAS2_HUMAN | GPCR -> Gprotein | gpDB |
| PD2R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
| GLHA_HUMAN | PD2R_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030238 | male sex determination | IEA | biological_process |
| GO:0006954 | inflammatory response | IEA | biological_process |
| GO:0046085 | adenosine metabolic process | IEA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | NAS | biological_process |
| GO:0004956 | prostaglandin D receptor activity | IEA | molecular_function |
| GO:0016021 | integral to membrane | NAS | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0001785 | prostaglandin J receptor activity | IEA | molecular_function |
| GO:0071799 | cellular response to prostaglandin D stimulus | IEA | biological_process |
| GO:0004956 | prostaglandin D receptor activity | NAS | molecular_function |
| GO:0030431 | sleep | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |