Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PAK3_HUMAN
Description:p21 protein (Cdc42/Rac)-activated kinase 3 [Source:HGNC Symbol;Acc:8592]
Location:chrX q23
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S154NQKYMsFTSGDautocatalysis RegPhos
T436QSKRStMVGTPPAK3RegPhos
Y477EGEPPyLNENPPkinasePhosphoSitePlus
T218TKSIYtRSVVEPhosphoSitePlus
S50KARLRsIFPGGPhosphoSitePlus
S435EQSKRsTMVGTPkinasePhosphoSitePlus
Y217HTKSIyTRSVVPhosphoSitePlus
S50KARLRsIFPGGautocatalysis RegPhos
S275LRSIVsVGDPKPhosphoSitePlus
Y298ASGTVyTALDIPkinasePhosphoSitePlus
T440STMVGtPYWMAPkinasePhosphoSitePlus
T421QSKRStMVGTPPAK3HPRD
T436QSKRStMVGTPPkinasePhosphoSitePlus
T59GGGDKtNKKKEPhosphoSitePlus
T436QSKRStMVGTPautocatalysis RegPhos
S558AIKNSsR____PhosphoSitePlus
S139NQKYMsFTSGDPAK3HPRD
S259RQRKKsKMTDEPhosphoSitePlus
S154NQKYMsFTSGDPAK3RegPhos
S154NQKYMsFTSGDRibosomal_60sPhosphoSitePlus

Dephosphorylation site
PAK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000401982R49LTCGAOvarian Cancer21720365, 18772890
ENSP00000410853S509PTCGAOvarian Cancer21720365, 18772890
ENSP00000361077R49LTCGAOvarian Cancer21720365, 18772890
ENSP00000262836E371GBIOMARTBreast Cancer21930507, 21930502
ENSP00000262836P73SBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000361077S509PTCGAOvarian Cancer21720365, 18772890
ENSP00000361077W339CTCGAOvarian Cancer21720365, 18772890
ENSP00000429113D204YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000410853W339CTCGAOvarian Cancer21720365, 18772890
ENSP00000262836T440SHPIColorectal Cancer17344846
ENSP00000361080E371GBIOMARTBreast Cancer21930507, 21930502
ENSP00000401982S509PTCGAOvarian Cancer21720365, 18772890
ENSP00000401982D183YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000361077E356GBIOMARTBreast Cancer21930507, 21930502
ENSP00000401982W339CTCGAOvarian Cancer21720365, 18772890
ENSP00000361077P53TDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000262836D198YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000361077D175VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000428921E392GBIOMARTBreast Cancer21930507, 21930502
ENSP00000429113E377GBIOMARTBreast Cancer21930507, 21930502
ENSP00000361080T440SHPIColorectal Cancer17344846
ENSP00000361077D183YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000353864E392GBIOMARTBreast Cancer21930507, 21930502
ENSP00000361077P193QDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000410853R49LTCGAOvarian Cancer21720365, 18772890
ENSP00000401982E356GBIOMARTBreast Cancer21930507, 21930502
ENSP00000410853D183YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000361080D198YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000361077T425SGreenman2007Intestines Cancer17344846, 18428421
ENSP00000389172E377GBIOMARTBreast Cancer21930507, 21930502
ENSP00000428921D219YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000389172D204YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000361077M138IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000353864D219YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000410853E356GBIOMARTBreast Cancer21930507, 21930502
ENSP00000361077V82LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
PAK3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PAK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PAK3_HUMANMYO6_HUMANkinase -> substrateHPRD; RegPhos
PAK3_HUMANPAK3_HUMANkinase -> substrateRegPhos
PAK3_HUMANRAF1_HUMANkinase -> substrateHPRD; RegPhos
PAK3_HUMANTNNI3_HUMANkinase -> substrateRegPhos
PAK3_HUMANSYN1_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04660T cell receptor signaling pathway
hsa04360Axon guidance
hsa04510Focal adhesion
hsa05211Renal cell carcinoma
hsa04810Regulation of actin cytoskeleton
hsa04012ErbB signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005083small GTPase regulator activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0016358dendrite developmentIEAbiological_process
GO:0000165MAPK cascadeIDAbiological_process
GO:0030833regulation of actin filament polymerizationIDAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0060997dendritic spine morphogenesisTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0006461protein complex assemblyIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0016358dendrite developmentISSbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0007409axonogenesisIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0008154actin polymerization or depolymerizationIEAbiological_process
GO:0050808synapse organizationTASbiological_process
GO:0017048Rho GTPase bindingIEAmolecular_function
GO:0007409axonogenesisISSbiological_process
GO:0000187activation of MAPK activityIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0015629actin cytoskeletonIEAcellular_component
GO:0051020GTPase bindingIEAmolecular_function
GO:0004708MAP kinase kinase activityIDAmolecular_function