Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MYO6_HUMAN
Description:myosin VI [Source:HGNC Symbol;Acc:7605]
Location:chr6 q14.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T661DKLRStGASFIMyosin_headPhosphoSitePlus
Y167KFVLRyLTESYMyosin_headPhosphoSitePlus
T88KDRIYtYVANIMyosin_headPhosphoSitePlus
S297LQNRKsPEYLKMyosin_headPhosphoSitePlus
S108IPKIYsSEAIKHPRD
S664RSTGAsFIRCIMyosin_headPhosphoSitePlus
Y300RKSPEyLKAGSMyosin_headPhosphoSitePlus
S1196YKDPQsKKKGWPhosphoSitePlus
Y100IAVNPyFDIPKMyosin_headPhosphoSitePlus
Y107DIPKIySSEAIHPRD
T402TTAGGtKGTVIHPRD
S82IKVRYsKDRIYHPRD
S660LDKLRsTGASFMyosin_headPhosphoSitePlus
T845LVKVGtLKKRLPhosphoSitePlus
T1283RQARPtYATAMPhosphoSitePlus
Y1137KSVTDyDFAPFHPRD
T405GGTKGtVIKVPPAK3HPRD; RegPhos
T1144APKSVtDYDFAPhosphoSitePlus
T405GGTKGtVIKVPMyosin_headPhosphoSitePlus
Y228GFVSHyLLEKSHPRD
S114SEAIKsYQGKSHPRD
Y1191RPADQyKDPQSPhosphoSitePlus
Y1284QARPTyATAMLPhosphoSitePlus
T891KSTMMtQEQIQHPRD
S109PKIYSsEAIKSMyosin_headPhosphoSitePlus
T405GGTKGtVIKVPRegPhos
Y1146KSVTDyDFAPFPhosphoSitePlus
S266EKLHLsSPDNFHPRD
S108IPKIYsSEAIKMyosin_headPhosphoSitePlus
T122GKSLGtRPPHVHPRD
T888AKIKStMMTQEHPRD
S911SEELLsALQKKPhosphoSitePlus
Y1121RRLKVyHAWKSPhosphoSitePlus
S109PKIYSsEAIKSHPRD
Y115EAIKSyQGKSLHPRD

Dephosphorylation site
MYO6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358994L1280VCOSMICOvarian Cancer21720365
ENSP00000358992Q797KBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000358994L265VBIOMARTBreast Cancer21930507, 21930502
ENSP00000358992L265VBIOMARTBreast Cancer21930507, 21930502
ENSP00000358994L311VCOSMICPancreatic Cancer
ENSP00000359002L265VBIOMARTBreast Cancer21930507, 21930502
ENSP00000358994L1057*BIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
MYO6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MYO6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PAK3_HUMANMYO6_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANMYO6_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
MYO6_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060001minus-end directed microfilament motor activityNASmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0042491auditory receptor cell differentiationIEAbiological_process
GO:0048839inner ear developmentIEAbiological_process
GO:0006605protein targetingIEAbiological_process
GO:0051015actin filament bindingISSmolecular_function
GO:0006897endocytosisISSbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0031941filamentous actinISScellular_component
GO:0016023cytoplasmic membrane-bounded vesicleIDAcellular_component
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0031965nuclear membraneIDAcellular_component
GO:0042472inner ear morphogenesisIEAbiological_process
GO:0051046regulation of secretionIMPbiological_process
GO:0005938cell cortexISScellular_component
GO:0003774motor activityISSmolecular_function
GO:0007416synapse assemblyIEAbiological_process
GO:0005654nucleoplasmIDAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0030665clathrin-coated vesicle membraneIEAcellular_component
GO:0030330DNA damage response, signal transduction by p53 clIDAbiological_process
GO:0030424axonIEAcellular_component
GO:0032587ruffle membraneIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0016461unconventional myosin complexTAScellular_component
GO:0043025neuronal cell bodyIEAcellular_component
GO:0048167regulation of synaptic plasticityIEAbiological_process
GO:0007268synaptic transmissionIEAbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0030139endocytic vesicleISScellular_component
GO:0071257cellular response to electrical stimulusIEAbiological_process
GO:0006897endocytosisIEAbiological_process
GO:0007626locomotory behaviorIEAbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0007605sensory perception of soundIEAbiological_process
GO:0045334clathrin-coated endocytic vesicleIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0014047glutamate secretionIEAbiological_process
GO:0016459myosin complexIEAcellular_component
GO:0005905coated pitIEAcellular_component
GO:0043531ADP bindingISSmolecular_function
GO:0012506vesicle membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0003779actin bindingTASmolecular_function
GO:0005829cytosolTAScellular_component
GO:0016358dendrite developmentIEAbiological_process
GO:0016591DNA-directed RNA polymerase II, holoenzymeIDAcellular_component
GO:0048471perinuclear region of cytoplasmISScellular_component
GO:0005737cytoplasmISScellular_component
GO:0001726ruffleIDAcellular_component
GO:0005516calmodulin bindingISSmolecular_function
GO:0006886intracellular protein transportISSbiological_process
GO:0030048actin filament-based movementISSbiological_process


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