| UniProt/SwissProt ID: | OXSR1_HUMAN |
| Description: | oxidative-stress responsive 1 [Source:HGNC Symbol;Acc:8508] |
| Location: | chr3 p22.2 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T185 | NKVRKtFVGTP | Pkinase | PhosphoSitePlus |
| S359 | ISQLRsPRVKE | PhosphoSitePlus | |
| T185 | NKVRKtFVGTP | WNK1 | phosphoELM |
| S312 | RAPTIsERAKK | PhosphoSitePlus | |
| T331 | GRLHKtEDGGW | PhosphoSitePlus; HPRD | |
| S425 | ALSSGsGSQET | HPRD; phosphoELM | |
| S369 | ESISNsELFPT | PhosphoSitePlus | |
| S325 | RVPGSsGRLHK | PhosphoSitePlus; HPRD | |
| T310 | LQRAPtISERA | PhosphoSitePlus | |
| S325 | RVPGSsGRLHK | WNK1 | phosphoELM |
| S347 | EFDEEsEEGKA | PhosphoSitePlus | |
| S355 | GKAAIsQLRSP | PhosphoSitePlus | |
| S339 | GGWEWsDDEFD | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S427 | SSGSGsQETKI | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S435 | TKIPIsLVLRL | OSR1_C | PhosphoSitePlus |
| T189 | KTFVGtPCWMA | Pkinase | PhosphoSitePlus |
| S325 | RVPGSsGRLHK | Wnk1 | RegPhos |
| T185 | NKVRKtFVGTP | Wnk1 | RegPhos |
| S263 | KKYGKsFRKMI | Pkinase | PhosphoSitePlus |
| S324 | RRVPGsSGRLH | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| OXSR1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000311713 | S355L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000311713 | S407C | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000311713 | V201F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000311713 | V201F | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000311713 | P433S | Greenman2007 | Skin Cancer | 17344846, 18428421 |
| Differential expressed protein |
| OXSR1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| OXSR1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| WNK1_HUMAN | OXSR1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | OXSR1_HUMAN | kinase -> substrate | RegPhos |
| OXSR1_HUMAN | RAP1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| OXSR1_HUMAN | PKN1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| OXSR1_HUMAN | S12A2_HUMAN | kinase -> substrate | RegPhos |
| OXSR1_HUMAN | EF1D_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| OXSR1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0000287 | magnesium ion binding | IDA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0006979 | response to oxidative stress | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0007243 | intracellular protein kinase cascade | IDA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |