Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:S12A2_HUMAN
Description:solute carrier family 12 (sodium/potassium/chloride transporters), member 2 [Source:HGNC Symbol;Acc:10911]
Location:chr5 q23.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T207DTHTNtYYLRTAA_permease_NPhosphoSitePlus
T212TYYLRtFGHNTAA_permease_NPhosphoSitePlus
T203HYYYDtHTNTYOXSR1HPRD
S77LGPTPsQSRFQPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T203HYYYDtHTNTYAA_permease_NPhosphoSitePlus
S1212VLTFYs_____PhosphoSitePlus
S994LLKKEsKGPIVPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S242KLLRPsLAELHAA_permease_NPhosphoSitePlus
T207DTHTNtYYLRTOXSR1HPRD
S79PTPSQsRFQVDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T212TYYLRtFGHNTOSR1RegPhos
T268EESTPtRDAVVAA_permease_NPhosphoSitePlus
T212TYYLRtFGHNTOXSR1HPRD
S953KDVVVsVEYSKPhosphoSitePlus
T276AVVTYtAESKGPhosphoSitePlus
T266NGEEStPTRDAAA_permease_NPhosphoSitePlus
S265ANGEEsTPTRDAA_permease_NPhosphoSitePlus
Y227PRIDHyRHTAAAA_permease_NPhosphoSitePlus
Y275DAVVTyTAESKPhosphoSitePlus
Y903RDVDMyINLFHTMPhosphoSitePlus
T203HYYYDtHTNTYOSR1RegPhos
Y208THTNTyYLRTFAA_permease_NPhosphoSitePlus
S940EELLSsQEKSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T984EEDGKtATQPLPhosphoSitePlus
T207DTHTNtYYLRTOSR1RegPhos
Y1211SVLTFyS____PhosphoSitePlus
T266NGEEStPTRDAphosphoELM
T230DHYRHtAAQLGAA_permease_NPhosphoSitePlus
T217TFGHNtMDAVPAA_permease_NPhosphoSitePlus
Y956VVSVEySKKSDPhosphoSitePlus

Dephosphorylation site
S12A2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262461S516*BIOMARTBreast Cancer21930507, 21930502
ENSP00000262461K889NCOSMICOvarian Cancer20826764
ENSP00000262461W714CTCGAOvarian Cancer21720365, 18772890
ENSP00000262461L657VCOSMICOvarian Cancer21720365
ENSP00000262461L657VTCGAOvarian Cancer21720365, 18772890
ENSP00000262461W714CCOSMICOvarian Cancer21720365
ENSP00000340878S516*BIOMARTBreast Cancer21930507, 21930502
ENSP00000262461V418LCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000262461Hepatocellular CarcinomaMetastasiscell lineUp2.519016532

Hyperphosphorylation site
S12A2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
OXSR1_HUMANS12A2_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANS12A2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05110Vibrio cholerae infection
hsa04972Pancreatic secretion
hsa04970Salivary secretion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0006810transportTASbiological_process
GO:0060444branching involved in mammary gland duct morphogenIEAbiological_process
GO:0035264multicellular organism growthIEAbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0015377cation:chloride symporter activityIEAmolecular_function
GO:0006814sodium ion transportIEAbiological_process
GO:0030321transepithelial chloride transportIDAbiological_process
GO:0051739ammonia transmembrane transporter activityIDAmolecular_function
GO:0006813potassium ion transportIEAbiological_process
GO:0016020membraneTAScellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0016324apical plasma membraneIEAcellular_component
GO:0050910detection of mechanical stimulus involved in sensoIEAbiological_process
GO:0060763mammary duct terminal end bud growthIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0008511sodium:potassium:chloride symporter activityTASmolecular_function
GO:0015696ammonium transportIDAbiological_process
GO:0006811ion transportTASbiological_process
GO:0070634transepithelial ammonium transportIDAbiological_process


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