Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:OPRD_HUMAN
Description:opioid receptor, delta 1 [Source:HGNC Symbol;Acc:8153]
Location:chr1 p35.3
Node attribute:substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T358ARERVtACTPSPhosphoSitePlus
S344RPDPSsFSRARPKC_groupphosphoELM; RegPhos
S363TACTPsDGPGGPhosphoSitePlus
T361RVTACtPSDGPADRBK1HPRD
S344RPDPSsFSRARPRKCAHPRD
S363TACTPsDGPGGBARK1(GRK2RegPhos
T358ARERVtACTPSADRBK1HPRD
S363TACTPsDGPGGGRK-2phosphoELM
T361RVTACtPSDGPGRK-2phosphoELM
S344RPDPSsFSRARPKCaRegPhos
S344RPDPSsFSRARPKCeRegPhos
T358ARERVtACTPSBARK1(GRK2RegPhos
T361RVTACtPSDGPBARK1(GRK2RegPhos
T358ARERVtACTPSBARK1RegPhos
S363TACTPsDGPGGBARK1RegPhos
S363TACTPsDGPGGADRBK1HPRD
S344RPDPSsFSRARPKCdRegPhos
S344RPDPSsFSRARPRKCDHPRD
S344RPDPSsFSRARPRKCEHPRD
T361RVTACtPSDGPPhosphoSitePlus
T361RVTACtPSDGPBARK1RegPhos
T358ARERVtACTPSGRK-2phosphoELM

Dephosphorylation site
OPRD_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000234961I86MBIOMARTBreast Cancer21930507, 21930502
ENSP00000234961T82MCOSMICCentral Nervous System Neoplasms18772396
ENSP00000234961S344RCOSMICOvarian Cancer21720365
ENSP00000234961R190SCOSMICOvarian Cancer21720365
ENSP00000234961A94SCOSMICHead and Neck Cancer21798893
ENSP00000234961R190STCGAOvarian Cancer21720365, 18772890
ENSP00000234961G194ECOSMICSkin Cancer21984974

Differential expressed protein
OPRD_HUMAN is not differential expressed protein.

Hyperphosphorylation site
OPRD_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANOPRD_HUMANkinase -> substrateHPRD
ARBK1_HUMANOPRD_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KPCD_HUMANOPRD_HUMANkinase -> substrateHPRD
KPCE_HUMANOPRD_HUMANkinase -> substrateHPRD
IP3KA_HUMANOPRD_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045121membrane raftIEAcellular_component
GO:0043679axon terminusIEAcellular_component
GO:0032590dendrite membraneIEAcellular_component
GO:0031982vesicleIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0051924regulation of calcium ion transportIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0016020membraneIEAcellular_component
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0038046enkephalin receptor activityIEAmolecular_function
GO:0008344adult locomotory behaviorIEAbiological_process
GO:0045211postsynaptic membraneIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0007187G-protein coupled receptor signaling pathway, coupTASbiological_process
GO:0000060protein import into nucleus, translocationIDAbiological_process
GO:0007218neuropeptide signaling pathwayIEAbiological_process
GO:0038003opioid receptor signaling pathwayIMPbiological_process
GO:0007200phospholipase C-activating G-protein coupled recepIEAbiological_process
GO:0004985opioid receptor activityIEAmolecular_function
GO:0006955immune responseTASbiological_process
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0051930regulation of sensory perception of painIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0038046enkephalin receptor activityIMPmolecular_function
GO:0007200phospholipase C-activating G-protein coupled recepISSbiological_process
GO:0007193adenylate cyclase-inhibiting G-protein coupled recIEAbiological_process


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