| UniProt/SwissProt ID: | OCLN_HUMAN |
| Description: | occludin [Source:HGNC Symbol;Acc:8104] |
| Location: | chr5 q13.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S40 | VRPMLsQPAYS | PhosphoSitePlus | |
| S378 | NFETPsKRAPA | PhosphoSitePlus | |
| S370 | QPRYSsGGNFE | PhosphoSitePlus | |
| S340 | RFYPEsSYKST | PRKCB | HPRD |
| S340 | RFYPEsSYKST | PRKCA | HPRD |
| T393 | GRSKRtEQDHY | DUF342; APG6 | PhosphoSitePlus |
| S341 | FYPESsYKSTP | PhosphoSitePlus | |
| Y342 | YPESSyKSTPV | PhosphoSitePlus | |
| T404 | ETDYTtGGESC | DUF342; APG6 | PhosphoSitePlus |
| Y368 | FRQPRySSGGN | PhosphoSitePlus; SysPTM | |
| T403 | YETDYtTGGES | DUF342; APG6 | PhosphoSitePlus |
| Y325 | DSPMAySSNGK | PhosphoSitePlus | |
| S327 | PMAYSsNGKVN | PhosphoSitePlus | |
| Y402 | HYETDyTTGGE | DUF342; APG6 | PhosphoSitePlus |
| Y337 | NDKRFyPESSY | PhosphoSitePlus | |
| Y287 | DKEHIyDEQPP | PhosphoSitePlus | |
| T305 | NVSAGtQDVPS | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S326 | SPMAYsSNGKV | PhosphoSitePlus | |
| S313 | VPSPPsDYVER | PhosphoSitePlus; HPRD | |
| S344 | ESSYKsTPVPE | PhosphoSitePlus | |
| S490 | KQVKGsADYKS | Occludin_ELL; DUF4151; DU | PhosphoSitePlus |
| S340 | RFYPEsSYKST | PhosphoSitePlus | |
| T376 | GGNFEtPSKRA | PhosphoSitePlus; HPRD | |
| T424 | EYPPItSDQQR | Occludin_ELL; DUF4151; DU | PhosphoSitePlus |
| S340 | RFYPEsSYKST | PKC_group | phosphoELM; RegPhos |
| Y467 | KELDDyREESE | Occludin_ELL; DUF4151; DU | PhosphoSitePlus |
| S340 | RFYPEsSYKST | PKCb | RegPhos |
| S340 | RFYPEsSYKST | PKCa | RegPhos |
| S340 | RFYPEsSYKST | PKCg | RegPhos |
| S310 | TQDVPsPPSDY | PhosphoSitePlus | |
| S408 | TTGGEsCDELE | CSNK2B | HPRD; SysPTM |
| S340 | RFYPEsSYKST | PRKCG | HPRD |
| Y443 | TGLQEyKSLQS | Occludin_ELL; DUF4151; DU | PhosphoSitePlus |
| Y481 | AAADEyNRLKQ | Occludin_ELL; DUF4151; DU | PhosphoSitePlus |
| Y474 | EESEEyMAAAD | Occludin_ELL; DUF4151; DU | PhosphoSitePlus |
| Y315 | SPPSDyVERVD | PhosphoSitePlus | |
| S45 | SQPAYsFYPED | PhosphoSitePlus | |
| S321 | VERVDsPMAYS | PhosphoSitePlus | |
| S408 | TTGGEsCDELE | P67870(Casein kinase II ) | RegPhos; SysPTM |
| T404 | ETDYTtGGESC | CSNK2B | HPRD |
| T404 | ETDYTtGGESC | CK2_group | phosphoELM; RegPhos |
| S369 | RQPRYsSGGNF | PhosphoSitePlus; HPRD; SysPTM | |
| Y398 | TEQDHyETDYT | DUF342; APG6 | PhosphoSitePlus |
| T438 | KRNFDtGLQEY | Occludin_ELL; DUF4151; DU | PhosphoSitePlus |
| Y44 | LSQPAySFYPE | PhosphoSitePlus | |
| S408 | TTGGEsCDELE | DUF342; APG6 | PhosphoSitePlus; SysPTM |
| T404 | ETDYTtGGESC | P67870(Casein kinase II ) | RegPhos |
| T345 | SSYKStPVPEV | PhosphoSitePlus | |
| S408 | TTGGEsCDELE | CK2_group | phosphoELM; RegPhos; SysPTM |
| T400 | QDHYEtDYTTG | DUF342; APG6 | PhosphoSitePlus |
| S358 | ELPLTsPVDDF | PhosphoSitePlus | |
| Dephosphorylation site |
| OCLN_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000379719 | A43T | COSMIC | Hepatocellular Carcinoma | 21822264 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000379719 | Breast Cancer | Treatment (tamoxifen-sensitive vs. tamoxifen-resistant) | tissue | Down | 0.54 | 19329653 |
| Hyperphosphorylation site |
| OCLN_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | OCLN_HUMAN | kinase -> substrate | RegPhos |
| CSK21_HUMAN | OCLN_HUMAN | kinase -> substrate | KEGG |
| KPCA_HUMAN | OCLN_HUMAN | kinase -> substrate | HPRD |
| KPCB_HUMAN | OCLN_HUMAN | kinase -> substrate | HPRD |
| CSK2B_HUMAN | OCLN_HUMAN | kinase -> substrate | HPRD |
| KPCG_HUMAN | OCLN_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05130 | Pathogenic Escherichia coli infection |
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa04530 | Tight junction |
| hsa04670 | Leukocyte transendothelial migration |
| hsa05160 | Hepatitis C |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030054 | cell junction | IDA | cellular_component |
| GO:0005911 | cell-cell junction | IEA | cellular_component |
| GO:0005923 | tight junction | IEA | cellular_component |
| GO:0006461 | protein complex assembly | TAS | biological_process |
| GO:0005923 | tight junction | IDA | cellular_component |
| GO:0005198 | structural molecule activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0045216 | cell-cell junction organization | IMP | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0016324 | apical plasma membrane | IEA | cellular_component |
| GO:0016327 | apicolateral plasma membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005911 | cell-cell junction | IDA | cellular_component |
| GO:0006921 | cellular component disassembly involved in executi | TAS | biological_process |