Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:OCLN_HUMAN
Description:occludin [Source:HGNC Symbol;Acc:8104]
Location:chr5 q13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S40VRPMLsQPAYSPhosphoSitePlus
S378NFETPsKRAPAPhosphoSitePlus
S370QPRYSsGGNFEPhosphoSitePlus
S340RFYPEsSYKSTPRKCBHPRD
S340RFYPEsSYKSTPRKCAHPRD
T393GRSKRtEQDHYDUF342; APG6PhosphoSitePlus
S341FYPESsYKSTPPhosphoSitePlus
Y342YPESSyKSTPVPhosphoSitePlus
T404ETDYTtGGESCDUF342; APG6PhosphoSitePlus
Y368FRQPRySSGGNPhosphoSitePlus; SysPTM
T403YETDYtTGGESDUF342; APG6PhosphoSitePlus
Y325DSPMAySSNGKPhosphoSitePlus
S327PMAYSsNGKVNPhosphoSitePlus
Y402HYETDyTTGGEDUF342; APG6PhosphoSitePlus
Y337NDKRFyPESSYPhosphoSitePlus
Y287DKEHIyDEQPPPhosphoSitePlus
T305NVSAGtQDVPSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S326SPMAYsSNGKVPhosphoSitePlus
S313VPSPPsDYVERPhosphoSitePlus; HPRD
S344ESSYKsTPVPEPhosphoSitePlus
S490KQVKGsADYKSOccludin_ELL; DUF4151; DUPhosphoSitePlus
S340RFYPEsSYKSTPhosphoSitePlus
T376GGNFEtPSKRAPhosphoSitePlus; HPRD
T424EYPPItSDQQROccludin_ELL; DUF4151; DUPhosphoSitePlus
S340RFYPEsSYKSTPKC_groupphosphoELM; RegPhos
Y467KELDDyREESEOccludin_ELL; DUF4151; DUPhosphoSitePlus
S340RFYPEsSYKSTPKCbRegPhos
S340RFYPEsSYKSTPKCaRegPhos
S340RFYPEsSYKSTPKCgRegPhos
S310TQDVPsPPSDYPhosphoSitePlus
S408TTGGEsCDELECSNK2BHPRD; SysPTM
S340RFYPEsSYKSTPRKCGHPRD
Y443TGLQEyKSLQSOccludin_ELL; DUF4151; DUPhosphoSitePlus
Y481AAADEyNRLKQOccludin_ELL; DUF4151; DUPhosphoSitePlus
Y474EESEEyMAAADOccludin_ELL; DUF4151; DUPhosphoSitePlus
Y315SPPSDyVERVDPhosphoSitePlus
S45SQPAYsFYPEDPhosphoSitePlus
S321VERVDsPMAYSPhosphoSitePlus
S408TTGGEsCDELEP67870(Casein kinase II )RegPhos; SysPTM
T404ETDYTtGGESCCSNK2BHPRD
T404ETDYTtGGESCCK2_groupphosphoELM; RegPhos
S369RQPRYsSGGNFPhosphoSitePlus; HPRD; SysPTM
Y398TEQDHyETDYTDUF342; APG6PhosphoSitePlus
T438KRNFDtGLQEYOccludin_ELL; DUF4151; DUPhosphoSitePlus
Y44LSQPAySFYPEPhosphoSitePlus
S408TTGGEsCDELEDUF342; APG6PhosphoSitePlus; SysPTM
T404ETDYTtGGESCP67870(Casein kinase II )RegPhos
T345SSYKStPVPEVPhosphoSitePlus
S408TTGGEsCDELECK2_groupphosphoELM; RegPhos; SysPTM
T400QDHYEtDYTTGDUF342; APG6PhosphoSitePlus
S358ELPLTsPVDDFPhosphoSitePlus

Dephosphorylation site
OCLN_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000379719A43TCOSMICHepatocellular Carcinoma21822264

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000379719Breast CancerTreatment (tamoxifen-sensitive vs. tamoxifen-resistant)tissueDown0.5419329653

Hyperphosphorylation site
OCLN_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANOCLN_HUMANkinase -> substrateRegPhos
CSK21_HUMANOCLN_HUMANkinase -> substrateKEGG
KPCA_HUMANOCLN_HUMANkinase -> substrateHPRD
KPCB_HUMANOCLN_HUMANkinase -> substrateHPRD
CSK2B_HUMANOCLN_HUMANkinase -> substrateHPRD
KPCG_HUMANOCLN_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05130Pathogenic Escherichia coli infection
hsa04514Cell adhesion molecules (CAMs)
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa05160Hepatitis C

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030054cell junctionIDAcellular_component
GO:0005911cell-cell junctionIEAcellular_component
GO:0005923tight junctionIEAcellular_component
GO:0006461protein complex assemblyTASbiological_process
GO:0005923tight junctionIDAcellular_component
GO:0005198structural molecule activityIEAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0045216cell-cell junction organizationIMPbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0006915apoptotic processTASbiological_process
GO:0016324apical plasma membraneIEAcellular_component
GO:0016327apicolateral plasma membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005911cell-cell junctionIDAcellular_component
GO:0006921cellular component disassembly involved in executiTASbiological_process


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