Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NTRK3_HUMAN
Description:neurotrophic tyrosine kinase, receptor, type 3 [Source:HGNC Symbol;Acc:8033]
Location:chr15 q25.3
Node attribute:receptor; kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y558FLAECyNLSPTPkinase_TyrPhosphoSitePlus
S701GDFGMsRDVYSPkinase_TyrPhosphoSitePlus
Y131NPHLRyINLSSLRR_8PhosphoSitePlus
Y710YSTDYyRLFNPPkinase_TyrPhosphoSitePlus
Y516IENPQyFRQGHPhosphoSitePlus; phosphoELM
T220SHVNLtVREGDI-setPhosphoSitePlus
Y709VYSTDyYRLFNPkinase_TyrPhosphoSitePlus
T386KNPLGtANQTII-setPhosphoSitePlus
Y705MSRDVySTDYYPkinase_TyrPhosphoSitePlus
Y800CPKEVyDVMLGPkinase_TyrPhosphoSitePlus

Dephosphorylation site
NTRK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000347397H677YGreenman2007Lung Cancer16140923, 17344846, 18293376, 18428421
ENSP00000347397R721FGreenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000354207Y766FHPILung Cancer18293376
ENSP00000354207R735HDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000444673*613YCOSMICRenal Cancer21248752
ENSP00000354207L336QGreenman2007, HPILung Cancer17344846, 18428421
ENSP00000318328*613YCOSMICRenal Cancer21248752
ENSP00000347397V307LGreenman2007Lung Cancer17344846, 18428421
ENSP00000377990R678QGreenman2007Breast Cancer15908952, 17344846, 18428421
ENSP00000354207H677YGreenman2007, HPILung Cancer16140923, 17344846, 18293376, 18428421, 17344846, 18293376, 17344846 18293376
ENSP00000318328*613WCOSMICOvarian Cancer21720365
ENSP00000354207L270MDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000354207S184CDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000347397R678QGreenman2007Breast Cancer15908952, 17344846, 18428421
ENSP00000354207W736CHPILung Cancer18293376
ENSP00000354207T149RGreenman2007, HPIGastric Cancer17344846, 18428421
ENSP00000377990H677YGreenman2007Lung Cancer16140923, 17344846, 18293376, 18428421
ENSP00000354207L248MDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000354207R745PHPILung Cancer18293376
ENSP00000377990L336QGreenman2007Lung Cancer17344846, 18428421
ENSP00000444673*613WCOSMICOvarian Cancer21720365
ENSP00000354207I783NDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000377990T149RGreenman2007Gastric Cancer17344846, 18428421
ENSP00000347397D405NBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000347397T149RGreenman2007Gastric Cancer17344846, 18428421
ENSP00000354207L152IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000354207T283KDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000354207A664SHPILung Cancer18293376
ENSP00000377990R721FGreenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000354207V307LGreenman2007, HPILung Cancer17344846, 18428421
ENSP00000377990V307LGreenman2007Lung Cancer17344846, 18428421
ENSP00000347397E322KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000347397L336QGreenman2007Lung Cancer17344846, 18428421
ENSP00000354207R735FHPINon-small cell lung carcinoma

Differential expressed protein
NTRK3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NTRK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NTF3_HUMANNTRK3_HUMANligand -> receptorHPMR
NTRK3_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
NTRK3_HUMANETS1_HUMANkinase -> substrateRobert H Newman (2013)
NTRK3_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:0006950response to stressIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0046777protein autophosphorylationIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0090102cochlea developmentIEAbiological_process
GO:0000187activation of MAPK activityIDAbiological_process
GO:0046875ephrin receptor bindingIEAmolecular_function
GO:0032856activation of Ras GTPase activityIDAbiological_process
GO:0019056modulation by virus of host transcriptionIEAbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0048712negative regulation of astrocyte differentiationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005030neurotrophin receptor activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0042490mechanoreceptor differentiationIEAbiological_process
GO:0043121neurotrophin bindingTASmolecular_function
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0033138positive regulation of peptidyl-serine phosphorylaIDAbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0001933negative regulation of protein phosphorylationIDAbiological_process
GO:0010628positive regulation of gene expressionIDAbiological_process
GO:0002039p53 bindingIPImolecular_function
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0048691positive regulation of axon extension involved in IEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0048678response to axon injuryIEAbiological_process
GO:2000251positive regulation of actin cytoskeleton reorganiIDAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0045471response to ethanolIEAbiological_process
GO:0050927positive regulation of positive chemotaxisIDAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0032148activation of protein kinase B activityIDAbiological_process
GO:0048665neuron fate specificationIEAbiological_process
GO:0071300cellular response to retinoic acidIEAbiological_process
GO:0060548negative regulation of cell deathIEAbiological_process
GO:0051412response to corticosterone stimulusIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0004714transmembrane receptor protein tyrosine kinase actIEAmolecular_function
GO:0001764neuron migrationIEAbiological_process