Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NRX1B_HUMAN
Description:neurexin 1 [Source:HGNC Symbol;Acc:8008]
Location:chr2 p16.3
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S428PSSAKsSNKNKPhosphoSitePlus
S424KEKQPsSAKSSPhosphoSitePlus
S425EKQPSsAKSSNPhosphoSitePlus

Dephosphorylation site
NRX1B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000341184V71LCOSMICHead and Neck Cancer21798893
ENSP00000341184R404LCOSMICOvarian Cancer21720365
ENSP00000341184R349IBIOMARTBreast Cancer21930507, 21930502
ENSP00000341184R109*COSMICSkin Cancer21984974
ENSP00000341184H146LCOSMICOvarian Cancer21720365

Differential expressed protein
NRX1B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NRX1B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NXPH1_HUMANNRX1B_HUMANligand -> receptorHPMR
NLGN3_HUMANNRX1B_HUMANligand -> receptorHPMR
NXPH3_HUMANNRX1B_HUMANligand -> receptorHPMR
NLGN2_HUMANNRX1B_HUMANligand -> receptorHPMR
NLGN1_HUMANNRX1B_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04514Cell adhesion molecules (CAMs)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0097109neuroligin family protein bindingISSmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0090004positive regulation of establishment of protein loISSbiological_process
GO:0097112gamma-aminobutyric acid receptor clusteringISSbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0097114N-methyl-D-aspartate receptor clusteringISSbiological_process
GO:0097120receptor localization to synapseISSbiological_process
GO:0097105presynaptic membrane assemblyISSbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0097091synaptic vesicle clusteringISSbiological_process
GO:0060325face morphogenesisIMPbiological_process
GO:0097119postsynaptic density protein 95 clusteringISSbiological_process
GO:0007157heterophilic cell-cell adhesionISSbiological_process
GO:0043473pigmentationIMPbiological_process
GO:0051968positive regulation of synaptic transmission, glutISSbiological_process
GO:0030139endocytic vesicleISScellular_component
GO:0005102receptor bindingISSmolecular_function
GO:0016339calcium-dependent cell-cell adhesionISSbiological_process
GO:0097118neuroligin clusteringISSbiological_process
GO:0007158neuron cell-cell adhesionISSbiological_process
GO:0097116gephyrin clusteringISSbiological_process
GO:0001525angiogenesisISSbiological_process
GO:0044295axonal growth coneISScellular_component
GO:0042734presynaptic membraneTAScellular_component
GO:0048306calcium-dependent protein bindingISSmolecular_function
GO:0097117guanylate kinase-associated protein clusteringISSbiological_process
GO:0045184establishment of protein localizationISSbiological_process
GO:0050839cell adhesion molecule bindingISSmolecular_function
GO:2000463positive regulation of excitatory postsynaptic memISSbiological_process
GO:0009986cell surfaceISScellular_component
GO:2000310regulation of N-methyl-D-aspartate selective glutaISSbiological_process
GO:0035176social behaviorIMPbiological_process
GO:0030054cell junctionIEAcellular_component
GO:0097104postsynaptic membrane assemblyISSbiological_process
GO:0023041neuronal signal transductionTASbiological_process
GO:2000311regulation of alpha-amino-3-hydroxy-5-methyl-4-isoISSbiological_process


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