Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NLGN2_HUMAN
Description:neuroligin 2 [Source:HGNC Symbol;Acc:14290]
Location:chr17 p13.1
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S713RCRRLsPPGGSPhosphoSitePlus
S718SPPGGsGSGVPPhosphoSitePlus

Dephosphorylation site
NLGN2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000305288S296FCOSMICSkin Cancer21984974
ENSP00000305288E577KCOSMICCentral Nervous System Neoplasms18772396
ENSP00000305288P624SCOSMICSkin Cancer21984974

Differential expressed protein
NLGN2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NLGN2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NLGN2_HUMANNRX2B_HUMANligand -> receptorHPMR
NLGN2_HUMANNRX3B_HUMANligand -> receptorHPMR
NLGN2_HUMANNRX1B_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04514Cell adhesion molecules (CAMs)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045211postsynaptic membraneNAScellular_component
GO:0097116gephyrin clusteringISSbiological_process
GO:2000463positive regulation of excitatory postsynaptic memIEAbiological_process
GO:0002087regulation of respiratory gaseous exchange by neurIEAbiological_process
GO:0032230positive regulation of synaptic transmission, GABAISSbiological_process
GO:0097104postsynaptic membrane assemblyISSbiological_process
GO:0005887integral to plasma membraneISScellular_component
GO:0035418protein localization to synapseIEAbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0097151positive regulation of inhibitory postsynaptic memISSbiological_process
GO:0051965positive regulation of synapse assemblyISSbiological_process
GO:0050804regulation of synaptic transmissionIEAbiological_process
GO:0009986cell surfaceISScellular_component
GO:0042734presynaptic membraneIEAcellular_component
GO:0097151positive regulation of inhibitory postsynaptic memIEAbiological_process
GO:0097105presynaptic membrane assemblyIEAbiological_process
GO:0042043neurexin family protein bindingISSmolecular_function
GO:0045202synapseIBAcellular_component
GO:0032230positive regulation of synaptic transmission, GABAIEAbiological_process
GO:0035641locomotory exploration behaviorIEAbiological_process
GO:0097116gephyrin clusteringIEAbiological_process
GO:0004872receptor activityIBAmolecular_function
GO:0016020membraneNAScellular_component
GO:2000463positive regulation of excitatory postsynaptic memISSbiological_process
GO:0097104postsynaptic membrane assemblyIEAbiological_process
GO:0007158neuron cell-cell adhesionISSbiological_process
GO:0051968positive regulation of synaptic transmission, glutISSbiological_process
GO:0016337cell-cell adhesionNASbiological_process
GO:0035418protein localization to synapseISSbiological_process
GO:0097119postsynaptic density protein 95 clusteringIEAbiological_process
GO:0051968positive regulation of synaptic transmission, glutIEAbiological_process
GO:0097105presynaptic membrane assemblyISSbiological_process
GO:0019233sensory perception of painIEAbiological_process
GO:0050839cell adhesion molecule bindingISSmolecular_function
GO:0045217cell-cell junction maintenanceNASbiological_process
GO:0050839cell adhesion molecule bindingIEAmolecular_function
GO:0016787hydrolase activityIEAmolecular_function
GO:0045202synapseIEAcellular_component
GO:0030054cell junctionIEAcellular_component
GO:0007416synapse assemblyISSbiological_process
GO:0060077inhibitory synapseISScellular_component
GO:2000311regulation of alpha-amino-3-hydroxy-5-methyl-4-isoISSbiological_process
GO:0097119postsynaptic density protein 95 clusteringISSbiological_process
GO:0072553terminal button organizationISSbiological_process
GO:0050885neuromuscular process controlling balanceIEAbiological_process
GO:2000311regulation of alpha-amino-3-hydroxy-5-methyl-4-isoIEAbiological_process