Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NLGN1_HUMAN
Description:neuroligin 1 [Source:HGNC Symbol;Acc:14291]
Location:chr3 q26.31
Node attribute:ligand; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y716FAALYyKKDKRPhosphoSitePlus
Y779ACPPDyTLAMRPhosphoSitePlus
Y689VDQRDySTELSPhosphoSitePlus

Dephosphorylation site
NLGN1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000392500D326ACOSMICPancreatic Cancer
ENSP00000354541R446SCOSMICSkin Cancer21984974
ENSP00000354541V129ICOSMICLung Cancer20016488
ENSP00000392500P118LCOSMICCentral Nervous System Neoplasms18772396
ENSP00000441108R446SCOSMICSkin Cancer21984974
ENSP00000392500R446SCOSMICSkin Cancer21984974
ENSP00000441108V205LCOSMICOvarian Cancer21720365
ENSP00000354541V205LTCGAOvarian Cancer21720365, 18772890
ENSP00000354541D326ACOSMICPancreatic Cancer
ENSP00000441108D326ACOSMICPancreatic Cancer
ENSP00000441108V129ICOSMICLung Cancer20016488
ENSP00000392500V129ICOSMICLung Cancer20016488
ENSP00000392500Y440HCOSMICHead and Neck Cancer
ENSP00000441108Y440HCOSMICHead and Neck Cancer
ENSP00000392500V205LTCGAOvarian Cancer21720365, 18772890
ENSP00000354541Y440HCOSMICHead and Neck Cancer
ENSP00000354541P118LCOSMICCentral Nervous System Neoplasms18772396
ENSP00000392500S666LCOSMICSkin Cancer21984974
ENSP00000354541S666LCOSMICSkin Cancer21984974
ENSP00000441108V205LTCGAOvarian Cancer21720365, 18772890
ENSP00000354541V205LCOSMICOvarian Cancer21720365
ENSP00000441108S666LCOSMICSkin Cancer21984974
ENSP00000354541M33IBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000441108P118LCOSMICCentral Nervous System Neoplasms18772396
ENSP00000392500V205LCOSMICOvarian Cancer21720365

Differential expressed protein
NLGN1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NLGN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NLGN1_HUMANNRX3B_HUMANligand -> receptorHPMR
NLGN1_HUMANNRX1B_HUMANligand -> receptorHPMR
NRX3B_HUMANNLGN1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04514Cell adhesion molecules (CAMs)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0035418protein localization to synapseIEAbiological_process
GO:0004872receptor activityISSmolecular_function
GO:2000463positive regulation of excitatory postsynaptic memIEAbiological_process
GO:2000310regulation of N-methyl-D-aspartate selective glutaISSbiological_process
GO:2000311regulation of alpha-amino-3-hydroxy-5-methyl-4-isoISSbiological_process
GO:0051260protein homooligomerizationISSbiological_process
GO:0097105presynaptic membrane assemblyISSbiological_process
GO:0005887integral to plasma membraneISScellular_component
GO:0007399nervous system developmentIEAbiological_process
GO:2000463positive regulation of excitatory postsynaptic memISSbiological_process
GO:0007399nervous system developmentISSbiological_process
GO:0045664regulation of neuron differentiationIEAbiological_process
GO:1900244positive regulation of synaptic vesicle endocytosiISSbiological_process
GO:0051968positive regulation of synaptic transmission, glutISSbiological_process
GO:1900029positive regulation of ruffle assemblyISSbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:2000310regulation of N-methyl-D-aspartate selective glutaIEAbiological_process
GO:0097104postsynaptic membrane assemblyISSbiological_process
GO:0097104postsynaptic membrane assemblyIEAbiological_process
GO:0014069postsynaptic densityTAScellular_component
GO:0030054cell junctionIEAcellular_component
GO:0008152metabolic processIEAbiological_process
GO:0010740positive regulation of intracellular protein kinasIEAbiological_process
GO:0050839cell adhesion molecule bindingIEAmolecular_function
GO:0045211postsynaptic membraneIEAcellular_component
GO:0051491positive regulation of filopodium assemblyISSbiological_process
GO:0097115neurexin clusteringIEAbiological_process
GO:0097091synaptic vesicle clusteringIEAbiological_process
GO:0097120receptor localization to synapseIEAbiological_process
GO:0051491positive regulation of filopodium assemblyIEAbiological_process
GO:0048789cytoskeletal matrix organization at active zoneISSbiological_process
GO:0016339calcium-dependent cell-cell adhesionIEAbiological_process
GO:0048789cytoskeletal matrix organization at active zoneIEAbiological_process
GO:0097115neurexin clusteringISSbiological_process
GO:0050839cell adhesion molecule bindingISSmolecular_function
GO:0030425dendriteISScellular_component
GO:0051968positive regulation of synaptic transmission, glutIEAbiological_process
GO:0032433filopodium tipIEAcellular_component
GO:0097113alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionISSbiological_process
GO:0010740positive regulation of intracellular protein kinasISSbiological_process
GO:0007158neuron cell-cell adhesionIEAbiological_process
GO:0016339calcium-dependent cell-cell adhesionISSbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0002087regulation of respiratory gaseous exchange by neurIEAbiological_process
GO:0006605protein targetingIEAbiological_process
GO:0051290protein heterotetramerizationIEAbiological_process
GO:0097120receptor localization to synapseISSbiological_process
GO:0004872receptor activityIEAmolecular_function
GO:0097114N-methyl-D-aspartate receptor clusteringIEAbiological_process
GO:0051965positive regulation of synapse assemblyISSbiological_process
GO:0007416synapse assemblyIEAbiological_process
GO:0097119postsynaptic density protein 95 clusteringISSbiological_process
GO:0045664regulation of neuron differentiationISSbiological_process
GO:0097091synaptic vesicle clusteringISSbiological_process
GO:0072553terminal button organizationIEAbiological_process
GO:0016787hydrolase activityIEAmolecular_function
GO:0042043neurexin family protein bindingISSmolecular_function
GO:0051965positive regulation of synapse assemblyIEAbiological_process
GO:0045184establishment of protein localizationIEAbiological_process
GO:0060999positive regulation of dendritic spine developmentISSbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0017146N-methyl-D-aspartate selective glutamate receptor IEAcellular_component
GO:0045184establishment of protein localizationISSbiological_process
GO:0007157heterophilic cell-cell adhesionIEAbiological_process
GO:1900244positive regulation of synaptic vesicle endocytosiIEAbiological_process
GO:0097105presynaptic membrane assemblyIEAbiological_process
GO:2000302positive regulation of synaptic vesicle exocytosisISSbiological_process
GO:0016080synaptic vesicle targetingIEAbiological_process
GO:0046983protein dimerization activityISSmolecular_function
GO:0045202synapseISScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:2000302positive regulation of synaptic vesicle exocytosisIEAbiological_process
GO:0050804regulation of synaptic transmissionIEAbiological_process
GO:0050808synapse organizationIEAbiological_process
GO:0032230positive regulation of synaptic transmission, GABAIEAbiological_process
GO:2000311regulation of alpha-amino-3-hydroxy-5-methyl-4-isoIEAbiological_process
GO:0007158neuron cell-cell adhesionISSbiological_process
GO:0007416synapse assemblyISSbiological_process
GO:0060999positive regulation of dendritic spine developmentIEAbiological_process
GO:0016080synaptic vesicle targetingISSbiological_process
GO:0045202synapseIEAcellular_component
GO:0072553terminal button organizationISSbiological_process
GO:1900029positive regulation of ruffle assemblyIEAbiological_process
GO:0023041neuronal signal transductionTASbiological_process
GO:0051260protein homooligomerizationIEAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0006605protein targetingISSbiological_process
GO:0007157heterophilic cell-cell adhesionISSbiological_process
GO:0032230positive regulation of synaptic transmission, GABAISSbiological_process
GO:0042043neurexin family protein bindingIEAmolecular_function
GO:0097113alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionIEAbiological_process
GO:0097119postsynaptic density protein 95 clusteringIEAbiological_process
GO:0009986cell surfaceISScellular_component