Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NLGN3_HUMAN
Description:neuroligin 3 [Source:HGNC Symbol;Acc:14289]
Location:chrX q13.1
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y441FVDNLyGYPEGCOesterasePhosphoSitePlus
Y443DNLYGyPEGKDCOesterasePhosphoSitePlus
S13PSLSLsPKPTVPhosphoSitePlus
S269ALRWVsENIAFCOesterasePhosphoSitePlus

Dephosphorylation site
NLGN3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363163R778CCOSMICOvarian Cancer21720365
ENSP00000363163P89QCOSMICHead and Neck Cancer21798893
ENSP00000363163Y482*COSMICOvarian Cancer21720365
ENSP00000363163T809NBIOMARTBreast Cancer21930507, 21930502
ENSP00000351591T829NBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
NLGN3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NLGN3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NLGN3_HUMANNRX1B_HUMANligand -> receptorHPMR
NLGN3_HUMANNRX2B_HUMANligand -> receptorHPMR
NLGN3_HUMANNRX3B_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04514Cell adhesion molecules (CAMs)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005887integral to plasma membraneISScellular_component
GO:0061001regulation of dendritic spine morphogenesisIEAbiological_process
GO:0035176social behaviorIEAbiological_process
GO:2000311regulation of alpha-amino-3-hydroxy-5-methyl-4-isoIEAbiological_process
GO:0007158neuron cell-cell adhesionISSbiological_process
GO:2000463positive regulation of excitatory postsynaptic memISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0048675axon extensionISSbiological_process
GO:0050839cell adhesion molecule bindingISSmolecular_function
GO:0060079regulation of excitatory postsynaptic membrane potIEAbiological_process
GO:0060080regulation of inhibitory postsynaptic membrane potISSbiological_process
GO:1900271regulation of long-term synaptic potentiationIEAbiological_process
GO:0004872receptor activityISSmolecular_function
GO:0097104postsynaptic membrane assemblyISSbiological_process
GO:0051965positive regulation of synapse assemblyISSbiological_process
GO:0006898receptor-mediated endocytosisISSbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0060080regulation of inhibitory postsynaptic membrane potIEAbiological_process
GO:2000310regulation of N-methyl-D-aspartate selective glutaIEAbiological_process
GO:0016787hydrolase activityIEAmolecular_function
GO:0042043neurexin family protein bindingIBAmolecular_function
GO:0051966regulation of synaptic transmission, glutamatergicIEAbiological_process
GO:0050808synapse organizationIMPbiological_process
GO:0030139endocytic vesicleISScellular_component
GO:0008542visual learningIEAbiological_process
GO:0051968positive regulation of synaptic transmission, glutISSbiological_process
GO:0051968positive regulation of synaptic transmission, glutIEAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0030054cell junctionIEAcellular_component
GO:0097104postsynaptic membrane assemblyIEAbiological_process
GO:0007416synapse assemblyISSbiological_process
GO:0060076excitatory synapseIDAcellular_component
GO:0050804regulation of synaptic transmissionIEAbiological_process
GO:0045202synapseISScellular_component
GO:0097105presynaptic membrane assemblyISSbiological_process
GO:2000969positive regulation of alpha-amino-3-hydroxy-5-metIEAbiological_process
GO:2000331regulation of terminal button organizationIEAbiological_process
GO:0060024rhythmic synaptic transmissionISSbiological_process
GO:0002087regulation of respiratory gaseous exchange by neurIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:2000463positive regulation of excitatory postsynaptic memIEAbiological_process
GO:2000969positive regulation of alpha-amino-3-hydroxy-5-metISSbiological_process
GO:0035176social behaviorIMPbiological_process