Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NRP1_HUMAN
Description:neuropilin 1 [Source:HGNC Symbol;Acc:8004]
Location:chr10 p11.22
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T827IKIDEtGSTPGPhosphoSitePlus
S47PGYPHsYHPSECUBPhosphoSitePlus
Y322PGEDSyREWIQF5_F8_type_CPhosphoSitePlus
Y297TASSQySTNWSF5_F8_type_CPhosphoSitePlus
Y920NTQSTySEA__PhosphoSitePlus
Y358YYVKTyKIDVSF5_F8_type_CPhosphoSitePlus
S321TPGEDsYREWIF5_F8_type_CPhosphoSitePlus
T30DKCGDtIKIESCUBPhosphoSitePlus
Y353ETKKKyYVKTYF5_F8_type_CPhosphoSitePlus
S894SERNLsALENYPhosphoSitePlus; HPRD
T919LNTQStYSEA_PhosphoSitePlus
T316PENGWtPGEDSF5_F8_type_CPhosphoSitePlus
S921TQSTYsEA___PhosphoSitePlus
Y920NTQSTySphosphoELM
Y899SALENyNFELVPhosphoSitePlus; HPRD
S267YSVLQsSVSEDPhosphoSitePlus
Y310RSRLNyPENGWF5_F8_type_CPhosphoSitePlus
S51HSYHPsEKCEWCUBPhosphoSitePlus

Dephosphorylation site
NRP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265371G423ACOSMICOvarian Cancer21720365
ENSP00000364001M245LBIOMARTBreast Cancer21930507, 21930502
ENSP00000364001G433EBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000265371F134LBIOMARTBreast Cancer21930507, 21930502
ENSP00000265371G788ECOSMICMelanoma21499247
ENSP00000265371E277KBIOMARTBreast Cancer21930507, 21930502
ENSP00000265371M245LBIOMARTBreast Cancer21930507, 21930502
ENSP00000364001E277KBIOMARTBreast Cancer21930507, 21930502
ENSP00000364001D666NBIOMARTBreast Cancer21930507, 21930502
ENSP00000363955M245LBIOMARTBreast Cancer21930507, 21930502
ENSP00000363955F134LBIOMARTBreast Cancer21930507, 21930502
ENSP00000265371D666NBIOMARTBreast Cancer21930507, 21930502
ENSP00000364001F134LBIOMARTBreast Cancer21930507, 21930502
ENSP00000363955E277KBIOMARTBreast Cancer21930507, 21930502
ENSP00000265371S170NCOSMICSkin Cancer21984974
ENSP00000265371G433ECOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000364001Prostate CancerTreatment (androgen-starved vs. androgen-stimulated)cell lineUp2.314729644

Hyperphosphorylation site
NRP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
VEGFA_HUMANNRP1_HUMANligand -> receptorHPMR
SEM3B_HUMANNRP1_HUMANligand -> receptorHPMR
PLGF_HUMANNRP1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043025neuronal cell bodyIEAcellular_component
GO:0030424axonIEAcellular_component
GO:0014911positive regulation of smooth muscle cell migratioTASbiological_process
GO:0035729cellular response to hepatocyte growth factor stimIMPbiological_process
GO:0007411axon guidanceNASbiological_process
GO:0048841regulation of axon extension involved in axon guidIEAbiological_process
GO:0017154semaphorin receptor activityIEAmolecular_function
GO:0030517negative regulation of axon extensionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0019955cytokine bindingNASmolecular_function
GO:0060301positive regulation of cytokine activityTASbiological_process
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIMPbiological_process
GO:0005883neurofilamentIEAcellular_component
GO:0002116semaphorin receptor complexNAScellular_component
GO:0016477cell migrationIEAbiological_process
GO:0048010vascular endothelial growth factor receptor signalIMPbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0060666dichotomous subdivision of terminal units involvedIEAbiological_process
GO:0021636trigeminal nerve morphogenesisIEAbiological_process
GO:0009887organ morphogenesisTASbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0060627regulation of vesicle-mediated transportTASbiological_process
GO:0048012hepatocyte growth factor receptor signaling pathwaIMPbiological_process
GO:0010595positive regulation of endothelial cell migrationTASbiological_process
GO:0005829cytosolIDAcellular_component
GO:0001569patterning of blood vesselsIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0005021vascular endothelial growth factor-activated recepNASmolecular_function
GO:0017154semaphorin receptor activityNASmolecular_function
GO:0030426growth coneIEAcellular_component
GO:0008201heparin bindingIEAmolecular_function
GO:0009986cell surfaceIEAcellular_component
GO:0019838growth factor bindingTASmolecular_function
GO:0007411axon guidanceIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0043235receptor complexTAScellular_component
GO:0048010vascular endothelial growth factor receptor signalIEAbiological_process
GO:0007413axonal fasciculationIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0038084vascular endothelial growth factor signaling pathwIEAbiological_process
GO:0009611response to woundingIEAbiological_process
GO:0015026coreceptor activityTASmolecular_function
GO:0005021vascular endothelial growth factor-activated recepIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0035767endothelial cell chemotaxisIMPbiological_process
GO:0016358dendrite developmentIEAbiological_process
GO:0048843negative regulation of axon extension involved in IEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0031410cytoplasmic vesicleTAScellular_component
GO:0048008platelet-derived growth factor receptor signaling IMPbiological_process
GO:0071526semaphorin-plexin signaling pathwayIEAbiological_process
GO:0001938positive regulation of endothelial cell proliferatTASbiological_process
GO:0048485sympathetic nervous system developmentIEAbiological_process
GO:0071526semaphorin-plexin signaling pathwayNASbiological_process


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