Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLGF_HUMAN
Description:placental growth factor [Source:HGNC Symbol;Acc:8893]
Location:chr14 q24.3
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y117GDRPSyVELTFPDGFPhosphoSitePlus
S116SGDRPsYVELTPDGFPhosphoSitePlus

Dephosphorylation site
PLGF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000451413*150LCOSMICHead and Neck Cancer21798893

Differential expressed protein
PLGF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PLGF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PLGF_HUMANNRP1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05211Renal cell carcinoma
hsa05323Rheumatoid arthritis
hsa05219Bladder cancer
hsa04510Focal adhesion
hsa05200Pathways in cancer
hsa04150mTOR signaling pathway
hsa05212Pancreatic cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001938positive regulation of endothelial cell proliferatIEAbiological_process
GO:0002040sprouting angiogenesisIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0007565female pregnancyIEAbiological_process
GO:0032870cellular response to hormone stimulusIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0031100organ regenerationIEAbiological_process
GO:0051781positive regulation of cell divisionIEAbiological_process
GO:0008201heparin bindingIEAmolecular_function
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0042493response to drugIEAbiological_process
GO:0060688regulation of morphogenesis of a branching structuIEAbiological_process
GO:0048010vascular endothelial growth factor receptor signalTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0008083growth factor activityIMPmolecular_function
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0007267cell-cell signalingTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0001658branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0030154cell differentiationIEAbiological_process


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