Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NRBP_HUMAN
Description:nuclear receptor binding protein 1 [Source:HGNC Symbol;Acc:7993]
Location:chr2 p23.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S12QTVLSsGSDPKHPRD
T431PPSVKtPTPEPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S11SQTVLsSGSDPPhosphoSitePlus
Y152IFITEyMSSGSPkinasePhosphoSitePlus
S49EEEEEsEDESEPhosphoSitePlus
S2____MsEGESQPhosphoSitePlus
T225SVAPDtINNHVPhosphoSitePlus
S6TVLSHPRD; SysPTM
S422QEEVTsPVVPPPhosphoSitePlus; HPRD; phosphoELM
T8EGESQtVLSSGPhosphoSitePlus; HPRD; SysPTM
T433SVKTPtPEPAEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S2GESQHPRD; phosphoELM
S14VLSSGsDPKVEPhosphoSitePlus; HPRD

Dephosphorylation site
NRBP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000233557P432LGreenman2007, HPIOvarian Cancer17344846, 18428421
ENSP00000233557Q73*Greenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000233557A326PTCGAOvarian Cancer21720365, 18772890
ENSP00000369181Q73*Greenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000369181A326PTCGAOvarian Cancer21720365, 18772890
ENSP00000369181P432LGreenman2007, HPIOvarian Cancer17344846, 18428421

Differential expressed protein
NRBP_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NRBP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NRBP_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
NRBP_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMANNRBP_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
NRBP_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005654nucleoplasmTAScellular_component
GO:0010467gene expressionTASbiological_process
GO:0005938cell cortexIEAcellular_component
GO:0006888ER to Golgi vesicle-mediated transportIDAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0030027lamellipodiumIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0042802identical protein bindingIEAmolecular_function
GO:0012505endomembrane systemIDAcellular_component
GO:0042803protein homodimerization activityIEAmolecular_function


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