| UniProt/SwissProt ID: | PLOD1_HUMAN |
| Description: | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 [Source:HGNC Symbol;Acc:9081] |
| Location: | chr1 p36.22 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y53 | AQFFNyKIQAL | PhosphoSitePlus | |
| S165 | YAPNLsKLVAE | HPRD | |
| Y632 | LYPGYyTRAQF | PhosphoSitePlus | |
| Y675 | RVGVDyEGGGC | 2OG-FeII_Oxy | PhosphoSitePlus |
| S525 | LWEVFsNPEDW | PhosphoSitePlus | |
| Y631 | KLYPGyYTRAQ | PhosphoSitePlus | |
| Y628 | MTEKLyPGYYT | PhosphoSitePlus | |
| T409 | IAPLMtRHGRL | PhosphoSitePlus; HPRD | |
| S154 | KRFLGsGGFIG | HPRD | |
| S146 | KYPVVsDGKRF | PhosphoSitePlus | |
| Dephosphorylation site |
| PLOD1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000196061 | R644C | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000196061 | V218M | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000196061 | Q123H | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000196061 | Breast Cancer | Metastasis | cell line | Up | 18729497 | ENSP00000196061 | Breast Cancer | Metastasis | cell line | Up | 10 | 18729497 |
| Hyperphosphorylation site |
| PLOD1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NKX25_HUMAN | PLOD1_HUMAN | TF -> target gene | TRANSFAC |
| PITX2_HUMAN | PLOD1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| PLOD1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016706 | oxidoreductase activity, acting on paired donors, | IEA | molecular_function |
| GO:0001666 | response to hypoxia | IEP | biological_process |
| GO:0005789 | endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0008475 | procollagen-lysine 5-dioxygenase activity | IEA | molecular_function |
| GO:0030867 | rough endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0006464 | cellular protein modification process | NAS | biological_process |
| GO:0030198 | extracellular matrix organization | TAS | biological_process |
| GO:0016705 | oxidoreductase activity, acting on paired donors, | IEA | molecular_function |
| GO:0046947 | hydroxylysine biosynthetic process | TAS | biological_process |
| GO:0042803 | protein homodimerization activity | TAS | molecular_function |
| GO:0005506 | iron ion binding | IEA | molecular_function |
| GO:0016491 | oxidoreductase activity | IEA | molecular_function |
| GO:0008544 | epidermis development | TAS | biological_process |
| GO:0031418 | L-ascorbic acid binding | IEA | molecular_function |
| GO:0016702 | oxidoreductase activity, acting on single donors w | IEA | molecular_function |
| GO:0055114 | oxidation-reduction process | TAS | biological_process |