| UniProt/SwissProt ID: | NFAT5_HUMAN |
| Description: | nuclear factor of activated T-cells 5, tonicity-responsive [Source:HGNC Symbol;Acc:7774] |
| Location: | chr16 q22.1 |
| Node attribute: | PPI(target); substrate; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S357 | TLQTPsSPILC | HPRD | |
| S648 | GNGSFsSPSSS | HPRD | |
| S69 | TVLYIsPPPED | HPRD | |
| S1197 | QTPMLsQEQAQ | ATM | phosphoELM; RegPhos |
| S17 | DLDLEsPKSLY | HPRD | |
| S484 | VKKEIsSPARP | HPRD | |
| S1247 | QSNSPsQEQQQ | ATM | phosphoELM; RegPhos |
| T135 | QQHPStPKRHT | HPRD | |
| S646 | IAGNGsFSSPS | HPRD | |
| S3 | FISL | HPRD | |
| S1367 | QGSPSsQEQQV | ATM | phosphoELM; RegPhos |
| S573 | NGSFSsPSSSH | HPRD | |
| S433 | TLQTPsSPILC | HPRD | |
| S570 | IAGNGsFSSPS | HPRD | |
| S649 | NGSFSsPSSSH | HPRD | |
| S560 | VKKEIsSPARP | HPRD | |
| S145 | TVLYIsPPPED | HPRD | |
| S572 | GNGSFsSPSSS | HPRD | |
| T59 | QQHPStPKRHT | HPRD | |
| Dephosphorylation site |
| NFAT5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000377343 | A1080V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000457593 | G39E | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000338806 | A1080V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000377343 | I440L | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000346420 | A1156V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000338806 | M525V | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 |
| Differential expressed protein |
| NFAT5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NFAT5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GSK3B_HUMAN | NFAT5_HUMAN | kinase -> substrate | KEGG |
| ATM_HUMAN | NFAT5_HUMAN | kinase -> substrate | RegPhos |
| CHP1_HUMAN | NFAT5_HUMAN | phosphatase -> substrate | KEGG |
| MK14_HUMAN | NFAT5_HUMAN | other | KEGG |
| NFAT5_HUMAN | PGH2_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04310 | Wnt signaling pathway |
| hsa04662 | B cell receptor signaling pathway |
| hsa04370 | VEGF signaling pathway |
| hsa04360 | Axon guidance |
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa05166 | HTLV-I infection |
| hsa04660 | T cell receptor signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0007165 | signal transduction | NAS | biological_process |
| GO:0007588 | excretion | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |