Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NEK7_HUMAN
Description:NIMA-related kinase 7 [Source:HGNC Symbol;Acc:13386]
Location:chr1 q31.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S147FVQLCsALEHMPkinasePhosphoSitePlus
T199HSLVGtPYYMSPkinasePhosphoSitePlus
Y97PNVIKyYASFIPkinasePhosphoSitePlus
Y201LVGTPyYMSPEPkinasePhosphoSitePlus
S187LGRFFsSKTTAPkinasePhosphoSitePlus
S5_MDEQsQGMQGPhosphoSitePlus
T199HSLVGtPYYMSHPRD
S195TTAAHsLVGTPNEK9HPRD; phosphoELM; RegPhos
S188GRFFSsKTTAAPkinasePhosphoSitePlus
S187LGRFFsSKTTAHPRD
T190FFSSKtTAAHSHPRD
T191FSSKTtAAHSLPkinasePhosphoSitePlus
Y202VGTPYyMSPERPkinasePhosphoSitePlus
S204TPYYMsPERIHHPRD; phosphoELM; SysPTM
Y289DVTYVyDVAKRPkinasePhosphoSitePlus
S195TTAAHsLVGTPPkinasePhosphoSitePlus
T286KRPDVtYVYDVPkinasePhosphoSitePlus
T30DMGYNtLANFRPhosphoSitePlus
T190FFSSKtTAAHSPkinasePhosphoSitePlus
S188GRFFSsKTTAAHPRD
Y244DKMNLySLCKKPkinasePhosphoSitePlus
S204TPYYMsPERIHPkinasePhosphoSitePlus; SysPTM
Y201LVGTPyYMSPEHPRD; phosphoELM
Y287RPDVTyVYDVAPkinasePhosphoSitePlus
Y202VGTPYyMSPERHPRD

Dephosphorylation site
NEK7_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356355G7*Greenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000356355I275MGreenman2007, HPIOvarian Cancer17344846, 18428421

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000356353Breast CancerNormal vs. Cancercell lineDown0.4720052998
ENSP00000356353Breast CancerNormal vs. Cancercell lineDown0.6520052998
ENSP00000356353Breast CancerMetastasiscell lineUp1.720052998

Hyperphosphorylation site
NEK7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NEK7_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
NEK7_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANNEK7_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
NEK7_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007346regulation of mitotic cell cycleTASbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0000922spindle poleIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005874microtubuleIEAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0005815microtubule organizing centerIEAcellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0051225spindle assemblyTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0000910cytokinesisTASbiological_process


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