| UniProt/SwissProt ID: | MMP3_HUMAN |
| Description: | matrix metallopeptidase 3 (stromelysin 1, progelatinase) [Source:HGNC Symbol;Acc:7173] |
| Location: | chr11 q22.2 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y42 | YLENYyDLKKD | PG_binding_1 | PhosphoSitePlus |
| Y116 | KTHLTyRIVNY | Peptidase_M10 | PhosphoSitePlus |
| Y121 | YRIVNyTPDLP | Peptidase_M10 | PhosphoSitePlus |
| Y18 | AVCSAyPLDGA | PhosphoSitePlus | |
| Y41 | KYLENyYDLKK | PG_binding_1 | PhosphoSitePlus |
| Y37 | NLVQKyLENYY | PG_binding_1 | PhosphoSitePlus |
| Dephosphorylation site |
| MMP3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000299855 | R316C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000299855 | S269F | COSMIC | Skin Cancer | 21984974 | ENSP00000299855 | A157G | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000299855 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.062 | 19053080 |
| Hyperphosphorylation site |
| MMP3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ETV4_HUMAN | MMP3_HUMAN | TF -> target gene | TRANSFAC |
| ZN148_HUMAN | MMP3_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| MMP3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004222 | metalloendopeptidase activity | IEA | molecular_function |
| GO:0030334 | regulation of cell migration | IEA | biological_process |
| GO:0008237 | metallopeptidase activity | IEA | molecular_function |
| GO:0005578 | proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0071230 | cellular response to amino acid stimulus | IEA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0031012 | extracellular matrix | IEA | cellular_component |
| GO:0030574 | collagen catabolic process | IEA | biological_process |
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0005615 | extracellular space | TAS | cellular_component |
| GO:0022617 | extracellular matrix disassembly | TAS | biological_process |
| GO:0030198 | extracellular matrix organization | TAS | biological_process |