UniProt/SwissProt ID: | MD1L1_HUMAN |
Description: | MAD1 mitotic arrest deficient-like 1 (yeast) [Source:HGNC Symbol;Acc:6762] |
Location: | chr7 p22.3 |
Node attribute: | substrate; PPI(source) |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
S90 | LERAAsTSARN | MAD; DUF2208 | PhosphoSitePlus |
S428 | TPAEYsPQLTR | MAD | PhosphoSitePlus; SysPTM |
S551 | SLNPTsVARQR | phosphoELM | |
T323 | ERLDQtMGLSI | HPRD | |
T13 | TMVLStLRSLN | phosphoELM | |
S428 | TPAEYsPQLTR | HPRD; phosphoELM; SysPTM | |
S92 | RAASTsARNYE | phosphoELM | |
S77 | MQMELsHKRAR | phosphoELM | |
S490 | SSAEQsFLFSR | MAD | PhosphoSitePlus |
Y634 | FRKACyTLTGY | MAD; DUF2856 | PhosphoSitePlus |
T680 | MQLLEtEFSHT | MAD | PhosphoSitePlus |
S490 | SSAEQsFLFSR | HPRD; phosphoELM | |
T550 | MSLNPtSVARQ | HPRD | |
S12 | NTMVLsTLRSL | HPRD; phosphoELM | |
Y649 | TTENQyRLTSL | MAD; DUF2856 | PhosphoSitePlus |
S12 | NTMVLsTLRSL | MAD | PhosphoSitePlus |
S29 | RVEGGsGLDIS | MAD | PhosphoSitePlus |
T13 | TMVLStLRSLN | MAD | PhosphoSitePlus |
S485 | LKSQSsSAEQS | HPRD | |
S185 | VKRLEsEKQEL | MAD; Reo_sigmaC | PhosphoSitePlus |
S77 | MQMELsHKRAR | MAD; DUF2208 | PhosphoSitePlus |
S22 | LNNFIsQRVEG | MAD | PhosphoSitePlus |
T708 | FLSSLtLELFS | MAD | PhosphoSitePlus |
S562 | LREDHsQLQAE | MAD | PhosphoSitePlus |
S598 | ASLPSsKEVAE | MAD; DUF2856 | PhosphoSitePlus |
S214 | QELQAsQEARA | HPRD; phosphoELM | |
Y427 | LTPAEySPQLT | HPRD; phosphoELM | |
Y535 | ALQGDyDQSRT | MAD | PhosphoSitePlus |
T432 | YSPQLtRRMRE | MAD | PhosphoSitePlus |
S16 | LSTLRsLNNFI | HPRD; phosphoELM; SysPTM | |
S90 | LERAAsTSARN | phosphoELM | |
S551 | SLNPTsVARQR | MAD | PhosphoSitePlus |
S597 | AASLPsSKEVA | MAD; DUF2856 | PhosphoSitePlus |
T583 | MERGGtVPADL | MAD | PhosphoSitePlus |
S699 | LRRQDsIPAFL | MAD | PhosphoSitePlus |
S92 | RAASTsARNYE | MAD; DUF2208 | PhosphoSitePlus |
S377 | ELRQVsGQLLE | MAD | PhosphoSitePlus |
S214 | QELQAsQEARA | MAD; Reo_sigmaC | PhosphoSitePlus |
S594 | EAAAAsLPSSK | HPRD | |
S16 | LSTLRsLNNFI | MAD | PhosphoSitePlus; SysPTM |
Dephosphorylation site |
MD1L1_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000385334 | R360Q | HPI | Prostate Cancer | 11423979 |
ENSP00000382562 | T299A | HPI | Lung Cancer | 10597320 |
ENSP00000385334 | T299A | HPI | Lung Cancer | 10597320 |
ENSP00000382562 | E569K | HPI | Breast Cancer | 11423979 |
ENSP00000382562 | S29L | HPI | Leukemia | 11423979 |
ENSP00000385334 | R558H | HPI | Other Cancer | 10366450 10597320 11423979 |
ENSP00000385334 | E516K | HPI | Breast Cancer | 11423979 |
ENSP00000382562 | R556H | HPI | Lung Cancer | 10597320 |
ENSP00000385334 | S29L | HPI | Leukemia | 11423979 |
ENSP00000382562 | R572H | HPI | Other Cancer | 10366450 |
ENSP00000385334 | R59C | OMIM, HPI | Prostate Cancer | 11423979 |
ENSP00000382562 | R59C | OMIM, HPI | Prostate Cancer | 11423979 |
ENSP00000382562 | R558H | HPI | Other Cancer | 10366450 10597320 11423979 |
ENSP00000382562 | E516K | HPI | Breast Cancer | 11423979 |
ENSP00000385334 | R572H | HPI | Other Cancer | 10366450 |
ENSP00000382562 | R360Q | HPI | Prostate Cancer | 11423979 |
ENSP00000385334 | E569K | HPI | Breast Cancer | 11423979 |
ENSP00000385334 | R556H | HPI | Lung Cancer | 10597320 |
Differential expressed protein |
MD1L1_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
MD1L1_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
TTK_HUMAN | MD1L1_HUMAN | kinase -> substrate | KEGG |
MD1L1_HUMAN | MD2L2_HUMAN | other | KEGG |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa05203 | Viral carcinogenesis |
hsa04110 | Cell cycle |
hsa04914 | Progesterone-mediated oocyte maturation |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0000093 | mitotic telophase | NAS | biological_process |
GO:0000278 | mitotic cell cycle | TAS | biological_process |
GO:0000776 | kinetochore | IDA | cellular_component |
GO:0000090 | mitotic anaphase | NAS | biological_process |
GO:0000236 | mitotic prometaphase | TAS | biological_process |
GO:0005643 | nuclear pore | IDA | cellular_component |
GO:0000089 | mitotic metaphase | NAS | biological_process |
GO:0000777 | condensed chromosome kinetochore | IEA | cellular_component |
GO:0005634 | nucleus | IDA | cellular_component |
GO:0005819 | spindle | NAS | cellular_component |
GO:0015629 | actin cytoskeleton | IDA | cellular_component |
GO:0000087 | M phase of mitotic cell cycle | TAS | biological_process |
GO:0005829 | cytosol | TAS | cellular_component |
GO:0051301 | cell division | IEA | biological_process |
GO:0007094 | mitotic cell cycle spindle assembly checkpoint | TAS | biological_process |
GO:0005737 | cytoplasm | IDA | cellular_component |
GO:0000075 | cell cycle checkpoint | TAS | biological_process |
GO:0005515 | protein binding | IPI | molecular_function |
GO:0005739 | mitochondrion | IDA | cellular_component |
GO:0007093 | mitotic cell cycle checkpoint | NAS | biological_process |
GO:0005813 | centrosome | NAS | cellular_component |