Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MC4R_HUMAN
Description:melanocortin 4 receptor [Source:HGNC Symbol;Acc:6932]
Location:chr18 q21.32
Node attribute:GPCR; receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S330LCDLSsADRBK1HPRD
S329GLCDLsSGRK-2phosphoELM
S330LCDLSsRYPKA_groupRegPhos
T312QELRKtFKEIIGRK_groupphosphoELM; RegPhos
T312QELRKtFKEIIBARK1RegPhos
S330LCDLSsRYBARK1(GRK2RegPhos
Y41SDGGCyEQLFVPhosphoSitePlus
T312QELRKtFKEIIPhosphoSitePlus
S330LCDLSsRYPKACaRegPhos
S330LCDLSsGRK_groupphosphoELM
S329GLCDLsSPRKACAHPRD
T312QELRKtFKEIIPKA_groupphosphoELM; RegPhos
S330LCDLSsRYGRK_groupRegPhos
T312QELRKtFKEIIPKACaRegPhos
T312QELRKtFKEIIADRBK1HPRD
S329GLCDLsSADRBK1HPRD
S330LCDLSsRYBARK1RegPhos
S329GLCDLsSRYBARK1(GRK2RegPhos
S329GLCDLsSRY__PhosphoSitePlus
S47EQLFVsPEVFVTMPhosphoSitePlus
S330LCDLSsGRK-2phosphoELM
S329GLCDLsSRYGRK_groupRegPhos
S36LGKGYsDGGCYPhosphoSitePlus
S330LCDLSsPRKACAHPRD
S330LCDLSsRY___PhosphoSitePlus
S329GLCDLsSRYPKACaRegPhos
S330LCDLSsPKA_groupphosphoELM
S329GLCDLsSRYPKA_groupRegPhos
T312QELRKtFKEIIPRKACAHPRD
S329GLCDLsSRYBARK1RegPhos
Y148IAVDRyFTIFY7tm_1PhosphoSitePlus
S329GLCDLsSPKA_groupphosphoELM
Y157FYALQyHNIMT7tm_1PhosphoSitePlus
S329GLCDLsSGRK_groupphosphoELM
Y35SLGKGySDGGCPhosphoSitePlus

Dephosphorylation site
MC4R_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000299766N3KCOSMICOvarian Cancer21720365
ENSP00000299766M161ICOSMICHead and Neck Cancer21798893
ENSP00000299766G34RCOSMICLung Cancer20668451

Differential expressed protein
MC4R_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MC4R_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AGRP_HUMANMC4R_HUMANligand -> receptorHPMR
MC4R_HUMANGNAS1_HUMANGPCR -> GproteingpDB
MC4R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
ARBK1_HUMANMC4R_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KPCA_HUMANMC4R_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:2000252negative regulation of feeding behaviorIEAbiological_process
GO:0045780positive regulation of bone resorptionIEAbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0006112energy reserve metabolic processIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0004980melanocyte-stimulating hormone receptor activityIEAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007631feeding behaviorIEAbiological_process
GO:0007188adenylate cyclase-modulating G-protein coupled recTASbiological_process
GO:0019222regulation of metabolic processIEAbiological_process
GO:0004977melanocortin receptor activityIEAmolecular_function
GO:0017046peptide hormone bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0032868response to insulin stimulusIEAbiological_process
GO:0004980melanocyte-stimulating hormone receptor activityIPImolecular_function
GO:0002024diet induced thermogenesisIEAbiological_process
GO:0004977melanocortin receptor activityTASmolecular_function
GO:0030819positive regulation of cAMP biosynthetic processIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0042923neuropeptide bindingIPImolecular_function
GO:0030073insulin secretionIEAbiological_process
GO:0045780positive regulation of bone resorptionIMPbiological_process