Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LYAM2_HUMAN
Description:selectin E [Source:HGNC Symbol;Acc:10718]
Location:chr1 q24.2
Node attribute:PPI(target); substrate; receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y603ESDGSyQKPSYHPRD

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y603SLESDGSyQKPSYILPTPN11HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000331736T514SCOSMICOvarian Cancer21720365
ENSP00000331736C394FCOSMICOvarian Cancer21720365
ENSP00000331736G152CCOSMICHead and Neck Cancer21798893
ENSP00000331736D243NBIOMARTBreast Cancer21930507, 21930502
ENSP00000331736H319YCOSMICMelanoma21499247
ENSP00000331736L284FCOSMICMelanoma21499247

Differential expressed protein
LYAM2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LYAM2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SELPL_HUMANLYAM2_HUMANligand -> receptorHPMR
PTN11_HUMANLYAM2_HUMANphosphatase -> substrateHPRD
SELPL_HUMANLYAM2_HUMANotherKEGG
JUN_HUMANLYAM2_HUMANTF -> target geneTRANSFAC
ATF3_HUMANLYAM2_HUMANTF -> target geneTRANSFAC
ATF2_HUMANLYAM2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04514Cell adhesion molecules (CAMs)
hsa05143African trypanosomiasis
hsa05144Malaria

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019722calcium-mediated signalingTASbiological_process
GO:0070555response to interleukin-1IDAbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0007202activation of phospholipase C activityIMPbiological_process
GO:0002687positive regulation of leukocyte migrationIEAbiological_process
GO:0004888transmembrane signaling receptor activityIMPmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0002092positive regulation of receptor internalizationIDAbiological_process
GO:0002523leukocyte migration involved in inflammatory respoTASbiological_process
GO:0034612response to tumor necrosis factorTASbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0030863cortical cytoskeletonIDAcellular_component
GO:0050901leukocyte tethering or rollingIMPbiological_process
GO:0050727regulation of inflammatory responseTASbiological_process
GO:0033691sialic acid bindingIDAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0032496response to lipopolysaccharideTASbiological_process
GO:0043274phospholipase bindingIDAmolecular_function
GO:0005905coated pitIDAcellular_component
GO:0005901caveolaIDAcellular_component
GO:0007157heterophilic cell-cell adhesionIMPbiological_process
GO:0045121membrane raftIDAcellular_component
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0007159leukocyte cell-cell adhesionIDAbiological_process
GO:0030029actin filament-based processIDAbiological_process
GO:0070492oligosaccharide bindingIDAmolecular_function
GO:0030246carbohydrate bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0050900leukocyte migrationIEAbiological_process


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