| UniProt/SwissProt ID: | LIPH_HUMAN |
| Description: | lipase, member H [Source:HGNC Symbol;Acc:18483] |
| Location: | chr3 q27.2 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S393 | KVAAIsLMFST | PhosphoSitePlus | |
| S29 | SFTRLsFHSAV | PhosphoSitePlus | |
| Dephosphorylation site |
| LIPH_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000296252 | D168N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000296252 | L411F | COSMIC | Skin Cancer | 21984974 | ENSP00000296252 | H330D | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000296252 | F73L | COSMIC | Pancreatic Cancer |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000296252 | Hepatocellular Carcinoma | Cancer vs. Cancer (HCC vs. HuCCA) | cell line | Up | 20069059 | |
| Hyperphosphorylation site |
| LIPH_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LIPH_HUMAN | LPAR4_HUMAN | ligand -> receptor | HPMR |
| LIPH_HUMAN | LPAR1_HUMAN | ligand -> receptor | HPMR |
| LIPH_HUMAN | LPAR2_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| LIPH_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016042 | lipid catabolic process | IDA | biological_process |
| GO:0008201 | heparin binding | IDA | molecular_function |
| GO:0005615 | extracellular space | IDA | cellular_component |
| GO:0004620 | phospholipase activity | IDA | molecular_function |
| GO:0005886 | plasma membrane | IDA | cellular_component |