| UniProt/SwissProt ID: | LAX1_HUMAN |
| Description: | lymphocyte transmembrane adaptor 1 [Source:HGNC Symbol;Acc:26005] |
| Location: | chr1 q32.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y373 | EDSSDyENVLT | PhosphoSitePlus | |
| Y93 | RAKNIyDILPW | PhosphoSitePlus | |
| Y345 | LASGDyADFQP | PhosphoSitePlus | |
| Dephosphorylation site |
| LAX1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| LAX1_HUMAN do not have mutation site. |
| Differential expressed protein |
| LAX1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| LAX1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LCK_HUMAN | LAX1_HUMAN | kinase -> substrate | NetPath |
| ZAP70_HUMAN | LAX1_HUMAN | kinase -> substrate | NetPath |
| KSYK_HUMAN | LAX1_HUMAN | kinase -> substrate | NetPath |
| Function Annotation |
| KEGG Pathway |
| LAX1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0046649 | lymphocyte activation | IEA | biological_process |
| GO:0042169 | SH2 domain binding | IDA | molecular_function |
| GO:0050868 | negative regulation of T cell activation | IDA | biological_process |
| GO:0000188 | inactivation of MAPK activity | IMP | biological_process |
| GO:0050851 | antigen receptor-mediated signaling pathway | IEA | biological_process |
| GO:0016021 | integral to membrane | IDA | cellular_component |
| GO:0042113 | B cell activation | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0048305 | immunoglobulin secretion | IEA | biological_process |
| GO:0019901 | protein kinase binding | IDA | molecular_function |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0035556 | intracellular signal transduction | IDA | biological_process |
| GO:0006955 | immune response | IDA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |