Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KPCL_HUMAN
Description:protein kinase C, eta [Source:HGNC Symbol;Acc:9403]
Location:chr14 q23.1
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S326KLVSRsTLRRQPhosphoSitePlus
T656EEPVLtPIDEGPkinase_CPhosphoSitePlus
S599TMRLGsLTQGGPkinase_AGCPhosphoSitePlus
S28QPTRWsLRHSLC2PhosphoSitePlus
S320NISPTsKLVSRHPRD
T183YLRQPtYCSHCC1_1PhosphoSitePlus
Y676FRNFSyVSPELPkinase_CPhosphoSitePlus
T656EEPVLtPIDEGHPRD
T601RLGSLtQGGEHPkinase_AGCPhosphoSitePlus
S32WSLRHsLFKKGC2PhosphoSitePlus
S675EFRNFsYVSPEPkinase_CPhosphoSitePlus
T513GVTTAtFCGTPPkinase_AGCPhosphoSitePlus
S365VLGKGsFGKVMPkinase_AGCPhosphoSitePlus
S317QPGNIsPTSKLPhosphoSitePlus; HPRD
Y94ETPLGyDHFVAC2PhosphoSitePlus

Dephosphorylation site
KPCL_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000329127T575AGreenman2007Neoplasms by Histologic Type17344846, 18428421
ENSP00000329127T594IGreenman2007Intestines Cancer17344846, 18428421
ENSP00000329127V374IBIOMARTGastric Cancer21930507, 21930502
ENSP00000329127G598VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000329127T594IHPIColorectal Cancer17344846
ENSP00000329127V390MTCGAOvarian Cancer21720365, 18772890
ENSP00000329127T575AGreenman2007Other Cancer(all cancer)17344846, 18428421

Differential expressed protein
KPCL_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KPCL_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCL_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
KPCL_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
KPCL_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
KPCL_HUMANKPCD1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCL_HUMANPTN11_HUMANkinase -> substrateHPRD
KPCL_HUMANITB2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCL_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04270Vascular smooth muscle contraction
hsa04530Tight junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050861positive regulation of B cell receptor signaling pIMPbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006468protein phosphorylationTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0060252positive regulation of glial cell proliferationIMPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005829cytosolIEAcellular_component
GO:0035556intracellular signal transductionIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0004697protein kinase C activityTASmolecular_function
GO:0004699calcium-independent protein kinase C activityIEAmolecular_function
GO:2000810regulation of tight junction assemblyIMPbiological_process
GO:0045618positive regulation of keratinocyte differentiatioIEAbiological_process
GO:0070528protein kinase C signaling cascadeIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIMPbiological_process
GO:0010744positive regulation of macrophage derived foam celIEAbiological_process
GO:0017160Ral GTPase bindingIEAmolecular_function
GO:0034351negative regulation of glial cell apoptotic procesIMPbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0030168platelet activationTASbiological_process


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