| UniProt/SwissProt ID: | KPCL_HUMAN |
| Description: | protein kinase C, eta [Source:HGNC Symbol;Acc:9403] |
| Location: | chr14 q23.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S326 | KLVSRsTLRRQ | PhosphoSitePlus | |
| T656 | EEPVLtPIDEG | Pkinase_C | PhosphoSitePlus |
| S599 | TMRLGsLTQGG | Pkinase_AGC | PhosphoSitePlus |
| S28 | QPTRWsLRHSL | C2 | PhosphoSitePlus |
| S320 | NISPTsKLVSR | HPRD | |
| T183 | YLRQPtYCSHC | C1_1 | PhosphoSitePlus |
| Y676 | FRNFSyVSPEL | Pkinase_C | PhosphoSitePlus |
| T656 | EEPVLtPIDEG | HPRD | |
| T601 | RLGSLtQGGEH | Pkinase_AGC | PhosphoSitePlus |
| S32 | WSLRHsLFKKG | C2 | PhosphoSitePlus |
| S675 | EFRNFsYVSPE | Pkinase_C | PhosphoSitePlus |
| T513 | GVTTAtFCGTP | Pkinase_AGC | PhosphoSitePlus |
| S365 | VLGKGsFGKVM | Pkinase_AGC | PhosphoSitePlus |
| S317 | QPGNIsPTSKL | PhosphoSitePlus; HPRD | |
| Y94 | ETPLGyDHFVA | C2 | PhosphoSitePlus |
| Dephosphorylation site |
| KPCL_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000329127 | T575A | Greenman2007 | Neoplasms by Histologic Type | 17344846, 18428421 | ENSP00000329127 | T594I | Greenman2007 | Intestines Cancer | 17344846, 18428421 | ENSP00000329127 | V374I | BIOMART | Gastric Cancer | 21930507, 21930502 | ENSP00000329127 | G598V | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000329127 | T594I | HPI | Colorectal Cancer | 17344846 | ENSP00000329127 | V390M | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000329127 | T575A | Greenman2007 | Other Cancer(all cancer) | 17344846, 18428421 |
| Differential expressed protein |
| KPCL_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KPCL_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCL_HUMAN | SRC8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCL_HUMAN | HNRPK_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCL_HUMAN | NPM_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCL_HUMAN | KPCD1_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| KPCL_HUMAN | PTN11_HUMAN | kinase -> substrate | HPRD |
| KPCL_HUMAN | ITB2_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| KPCL_HUMAN | ZAP70_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04270 | Vascular smooth muscle contraction |
| hsa04530 | Tight junction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0050861 | positive regulation of B cell receptor signaling p | IMP | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | TAS | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0060252 | positive regulation of glial cell proliferation | IMP | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0019899 | enzyme binding | IPI | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004697 | protein kinase C activity | TAS | molecular_function |
| GO:0004699 | calcium-independent protein kinase C activity | IEA | molecular_function |
| GO:2000810 | regulation of tight junction assembly | IMP | biological_process |
| GO:0045618 | positive regulation of keratinocyte differentiatio | IEA | biological_process |
| GO:0070528 | protein kinase C signaling cascade | IEA | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0051092 | positive regulation of NF-kappaB transcription fac | IMP | biological_process |
| GO:0010744 | positive regulation of macrophage derived foam cel | IEA | biological_process |
| GO:0017160 | Ral GTPase binding | IEA | molecular_function |
| GO:0034351 | negative regulation of glial cell apoptotic proces | IMP | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0030168 | platelet activation | TAS | biological_process |