Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CFLAR_HUMAN
Description:CASP8 and FADD-like apoptosis regulator [Source:HGNC Symbol;Acc:1876]
Location:chr2 q33.1
Node attribute:substrate; ubiquitination(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y182GAGTSyRNVLQPhosphoSitePlus
Y171TKIQKyKQSVQDEDPhosphoSitePlus
S314VCVLVsRGGSQPeptidase_C14PhosphoSitePlus
S273RDTFTsLGYEVPeptidase_C14PhosphoSitePlus
S193AAIQKsLKDPSPhosphoSitePlus

Dephosphorylation site
CFLAR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000411535L293VBIOMARTGastric Cancer21930507, 21930502

Differential expressed protein
CFLAR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CFLAR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANCFLAR_HUMANkinase -> substrateNetPath
ITCH_HUMANCFLAR_HUMANubiquitinationNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04210Apoptosis
hsa04064NF-kappa B signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019048virus-host interactionIEAbiological_process
GO:0014732skeletal muscle atrophyISSbiological_process
GO:1901740negative regulation of myoblast fusionISSbiological_process
GO:0002020protease bindingIPImolecular_function
GO:0043085positive regulation of catalytic activityIDAbiological_process
GO:0014866skeletal myofibril assemblyISSbiological_process
GO:0008047enzyme activator activityIDAmolecular_function
GO:2001237negative regulation of extrinsic apoptotic signaliIMPbiological_process
GO:0006508proteolysisIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facISSbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0014842regulation of satellite cell proliferationISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0031264death-inducing signaling complexIDAcellular_component
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEPbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0043403skeletal muscle tissue regenerationISSbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0008234cysteine-type peptidase activityIEAmolecular_function
GO:0004197cysteine-type endopeptidase activityIEAmolecular_function
GO:0007519skeletal muscle tissue developmentISSbiological_process


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