| UniProt/SwissProt ID: | IRK12_HUMAN |
| Description: | potassium inwardly-rectifying channel, subfamily J, member 12 [Source:HGNC Symbol;Acc:6258] |
| Location: | chrHG987_PATCH p11.2 |
| Node attribute: | effector; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S64 | NMDEKsQRYLA | IRK | PhosphoSitePlus |
| S431 | PYRREs | PRKACA | HPRD |
| T354 | YEVPStPRCSA | IRK | PhosphoSitePlus |
| S405 | SRDGLsPQARH | PhosphoSitePlus; HPRD; phosphoELM | |
| T38 | NGKVHtRRRCR | IRK_N | PhosphoSitePlus |
| Dephosphorylation site |
| IRK12_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000328150 | E334D | BIOMART | Brain Cancer | 21930507, 21930502 | ENSP00000328150 | E154K | COSMIC | Melanoma | 21499247 | ENSP00000328150 | R356H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000328150 | S343L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000328150 | I295N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000328150 | R356H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000328150 | R229G | COSMIC | Skin Cancer | 21984974 | ENSP00000328150 | P235L | COSMIC | Skin Cancer | 21984974 | ENSP00000328150 | E378K | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000328150 | *434Y | COSMIC | Ovarian Cancer | 20826764 | ENSP00000328150 | S343L | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| IRK12_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IRK12_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GBG8_HUMAN | IRK12_HUMAN | Gprotein -> effector | gpDB |
| GBB2_HUMAN | IRK12_HUMAN | Gprotein -> effector | gpDB |
| GBG13_HUMAN | IRK12_HUMAN | Gprotein -> effector | gpDB |
| GBB5_HUMAN | IRK12_HUMAN | Gprotein -> effector | gpDB |
| GBG1_HUMAN | IRK12_HUMAN | Gprotein -> effector | gpDB |
| GBG5_HUMAN | IRK12_HUMAN | Gprotein -> effector | gpDB |
| GBG12_HUMAN | IRK12_HUMAN | Gprotein -> effector | gpDB |
| GBG3_HUMAN | IRK12_HUMAN | Gprotein -> effector | gpDB |
| GBG10_HUMAN | IRK12_HUMAN | Gprotein -> effector | gpDB |
| GBG2_HUMAN | IRK12_HUMAN | Gprotein -> effector | gpDB |
| GBB1_HUMAN | IRK12_HUMAN | Gprotein -> effector | gpDB |
| GBB3_HUMAN | IRK12_HUMAN | Gprotein -> effector | gpDB |
| GBG11_HUMAN | IRK12_HUMAN | Gprotein -> effector | gpDB |
| KPCA_HUMAN | IRK12_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04725 | Cholinergic synapse |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006813 | potassium ion transport | TAS | biological_process |
| GO:0015459 | potassium channel regulator activity | TAS | molecular_function |
| GO:0006936 | muscle contraction | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0008200 | ion channel inhibitor activity | TAS | molecular_function |
| GO:0005242 | inward rectifier potassium channel activity | IEA | molecular_function |
| GO:0008015 | blood circulation | NAS | biological_process |
| GO:0008016 | regulation of heart contraction | TAS | biological_process |