Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IRAK3_HUMAN
Description:interleukin-1 receptor-associated kinase 3 [Source:HGNC Symbol;Acc:17020]
Location:chr12 q14.3
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S510TPFECsQSEVMPhosphoSitePlus
S154LKSSIsFQNIIPhosphoSitePlus
S110YGAVLsPSEKSPhosphoSitePlus
S398KRGLDsCLSFLPkinasePhosphoSitePlus
T188EIQNLtYAVKLPkinasePhosphoSitePlus
Y189IQNLTyAVKLFPkinasePhosphoSitePlus
S512FECSQsEVMFLPhosphoSitePlus
S401LDSCLsFLDKKPkinasePhosphoSitePlus
S467SFRCPsPLFLEPhosphoSitePlus
T162NIIEGtRNFHKPhosphoSitePlus
S415CPRNFsAKLFCPkinasePhosphoSitePlus
S484VEDDEsQNNNLPhosphoSitePlus

Dephosphorylation site
IRAK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261233E178QBIOMARTBreast Cancer21930507, 21930502
ENSP00000409852V306ATCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000409852M253ITCGAOvarian Cancer21720365, 18772890
ENSP00000409852E117QBIOMARTBreast Cancer21930507, 21930502
ENSP00000409852L360VTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
IRAK3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IRAK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IRAK3_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
IRAK3_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
IRAK3_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
IRAK3_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
IRAK3_HUMANATPK_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
IRAK3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032695negative regulation of interleukin-12 productionISSbiological_process
GO:0043330response to exogenous dsRNAIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIMPbiological_process
GO:0043244regulation of protein complex disassemblyISSbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0034122negative regulation of toll-like receptor signalinIEAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0043407negative regulation of MAP kinase activityIMPbiological_process
GO:0032695negative regulation of interleukin-12 productionIEAbiological_process
GO:0010936negative regulation of macrophage cytokine productIEAbiological_process
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0001960negative regulation of cytokine-mediated signalingICbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0042803protein homodimerization activityIPImolecular_function
GO:0043242negative regulation of protein complex disassemblyIMPbiological_process
GO:0010933positive regulation of macrophage tolerance inductIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0070498interleukin-1-mediated signaling pathwayIMPbiological_process
GO:0032494response to peptidoglycanIEAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0009615response to virusICbiological_process
GO:0010936negative regulation of macrophage cytokine productISSbiological_process
GO:0032720negative regulation of tumor necrosis factor produIMPbiological_process
GO:0042177negative regulation of protein catabolic processIMPbiological_process
GO:0070498interleukin-1-mediated signaling pathwayIEAbiological_process
GO:0032088negative regulation of NF-kappaB transcription facIMPbiological_process
GO:0043244regulation of protein complex disassemblyIEAbiological_process
GO:0043330response to exogenous dsRNAISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIDAcellular_component
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0032494response to peptidoglycanISSbiological_process
GO:0032496response to lipopolysaccharideISSbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0032715negative regulation of interleukin-6 productionIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0032715negative regulation of interleukin-6 productionISSbiological_process
GO:0045824negative regulation of innate immune responseIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayISSbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0034122negative regulation of toll-like receptor signalinISSbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0045824negative regulation of innate immune responseISSbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0010933positive regulation of macrophage tolerance inductISSbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIEAbiological_process
GO:0070555response to interleukin-1IMPbiological_process