Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IF5_HUMAN
Description:eukaryotic translation initiation factor 5 [Source:HGNC Symbol;Acc:3299]
Location:chr14 q32.32
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S389EAEEEsSGGEECSNK2A1HPRD; SysPTM
Y16DQFYRyKMPRLeIF-5_eIF-2BPhosphoSitePlus
S390AEEESsGGEEECK2_alphaphosphoELM
S10VNRSVsDQFYRHPRD; phosphoELM; SysPTM
S174ENGSVsSSETPCK2a1-rsRegPhos
Y16DQFYRyKMPRLHPRD
S390AEEESsGGEEECK2a1(CK2 alphaRegPhos
T208WGEDTtEEAQRPhosphoSitePlus
S390AEEESsGGEEECSNK2BHPRD
S389EAEEEsSGGEECK2a1(CK2 alphaRegPhos; SysPTM
S174ENGSVsSSETPP67870(Casein kinase II )RegPhos
S389EAEEEsSGGEECK2_alphaphosphoELM; SysPTM
S389EAEEEsSGGEECK2a1RegPhos; SysPTM
S176GSVSSsETPPPPhosphoSitePlus
S389EAEEEsSGGEEW2PhosphoSitePlus; SysPTM
S149NPPENsDSGTGPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S390AEEESsGGEEEphosphoELM; RegPhos
S390AEEESsGGEEEP67870(Casein kinase II )RegPhos
S174ENGSVsSSETPCK2a1RegPhos
S406IEVVYsKAASVPhosphoSitePlus
S10VNRSVsDQFYReIF-5_eIF-2BPhosphoSitePlus; SysPTM
S389EAEEEsSGGEECSNK2BHPRD; SysPTM
S229KVLTLsDDLERPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S390AEEESsGGEEECK2a1RegPhos
Y405NIEVVySKAASPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y362KASKKyVSKELW2PhosphoSitePlus
S174ENGSVsSSETPCSNK2A1HPRD
T227HAKVLtLSDDLPhosphoSitePlus; HPRD; SysPTM
S390AEEESsGGEEECK2a1-rsRegPhos
S419VETVKsDNKDDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S389EAEEEsSGGEEphosphoELM; RegPhos; SysPTM
S175NGSVSsSETPPPhosphoSitePlus
T207DWGEDtTEEAQPhosphoSitePlus
S390AEEESsGGEEECSNK2A1HPRD
S390AEEESsGGEEEW2PhosphoSitePlus
S389EAEEEsSGGEECK2a1-rsRegPhos; SysPTM
S410YSKAAsVPKVEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S174ENGSVsSSETPCSNK2BHPRD
S389EAEEEsSGGEEP67870(Casein kinase II )RegPhos; SysPTM

Dephosphorylation site
IF5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376477M195VCOSMICPancreatic Cancer
ENSP00000376477K418MSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000216554K418MSjoblom2006, HPIBreast Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000376477Breast CancerTreatment (tamoxifen-sensitive vs. tamoxifen-resistant)tissueUp219329653

Hyperphosphorylation site
IF5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANIF5_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK2B_HUMANIF5_HUMANkinase -> substrateHPRD
ZAGL2_HUMANIF5_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03013RNA transport

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008135translation factor activity, nucleic acid bindingTASmolecular_function
GO:0005488bindingIEAmolecular_function
GO:0006184GTP catabolic processTASbiological_process
GO:0005829cytosolNAScellular_component
GO:0044267cellular protein metabolic processTASbiological_process
GO:0006412translationTASbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0006413translational initiationNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0003743translation initiation factor activityIEAmolecular_function
GO:0010467gene expressionTASbiological_process
GO:0016070RNA metabolic processIEAbiological_process
GO:0006446regulation of translational initiationTASbiological_process
GO:0003924GTPase activityTASmolecular_function
GO:0005737cytoplasmIDAcellular_component


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