| UniProt/SwissProt ID: | IEX1_HUMAN |
| Description: | immediate early response 3 [Source:HGNC Symbol;Acc:5392] |
| Location: | chrHSCHR6_MHC_COX p2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S31 | GPRRGsGPEIF | PhosphoSitePlus; HPRD; phosphoELM | |
| T18 | ILQAPtPAPST | Erk3(MAPK6 | RegPhos |
| T18 | ILQAPtPAPST | MAPK1 | HPRD |
| T18 | ILQAPtPAPST | MAPK6 | phosphoELM |
| S55 | GRPSAsRGHRK | HPRD; phosphoELM | |
| T18 | ILQAPtPAPST | Erk2 | RegPhos |
| T18 | ILQAPtPAPST | PhosphoSitePlus | |
| S53 | PAGRPsASRGH | HPRD; phosphoELM | |
| Dephosphorylation site |
| IEX1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000259874 | A107G | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000259874 | *157S | COSMIC | Melanoma | 9354451 |
| Differential expressed protein |
| IEX1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IEX1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK01_HUMAN | IEX1_HUMAN | kinase -> substrate | HPRD |
| MK06_HUMAN | IEX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| IEX1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:2001020 | regulation of response to DNA damage stimulus | IMP | biological_process |
| GO:0001562 | response to protozoan | IEA | biological_process |
| GO:0042981 | regulation of apoptotic process | IEA | biological_process |
| GO:0009653 | anatomical structure morphogenesis | TAS | biological_process |
| GO:0045820 | negative regulation of glycolysis | IEA | biological_process |
| GO:0050728 | negative regulation of inflammatory response | IEA | biological_process |
| GO:2000377 | regulation of reactive oxygen species metabolic pr | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0043066 | negative regulation of apoptotic process | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0045732 | positive regulation of protein catabolic process | IEA | biological_process |
| GO:0003085 | negative regulation of systemic arterial blood pre | IEA | biological_process |
| GO:0043065 | positive regulation of apoptotic process | IEA | biological_process |