Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ICOSL_HUMAN
Description:inducible T-cell co-stimulator ligand [Source:HGNC Symbol;Acc:17087]
Location:chr21 q22.3
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T56YVYWQtSESKTPhosphoSitePlus

Dephosphorylation site
ICOSL_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000339477*310SCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000384432Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineUp5.119800108

Hyperphosphorylation site
ICOSL_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ICOSL_HUMANICOS_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04672Intestinal immune network for IgA production
hsa04514Cell adhesion molecules (CAMs)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016021integral to membraneNAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0007165signal transductionNASbiological_process
GO:0042113B cell activationIEAbiological_process
GO:0006952defense responseNASbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0005887integral to plasma membraneIEAcellular_component
GO:0042110T cell activationNASbiological_process
GO:0042104positive regulation of activated T cell proliferatTASbiological_process
GO:0045404positive regulation of interleukin-4 biosynthetic IEAbiological_process
GO:0005102receptor bindingTASmolecular_function
GO:0006972hyperosmotic responseNASbiological_process
GO:0031295T cell costimulationTASbiological_process


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