| UniProt/SwissProt ID: | ICOSL_HUMAN |
| Description: | inducible T-cell co-stimulator ligand [Source:HGNC Symbol;Acc:17087] |
| Location: | chr21 q22.3 |
| Node attribute: | PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T56 | YVYWQtSESKT | PhosphoSitePlus | |
| Dephosphorylation site |
| ICOSL_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000339477 | *310S | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000384432 | Ovarian Cancer | Treatment (cisplatin-sensitive vs. cisplatin-resistant) | cell line | Up | 5.1 | 19800108 |
| Hyperphosphorylation site |
| ICOSL_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ICOSL_HUMAN | ICOS_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04672 | Intestinal immune network for IgA production |
| hsa04514 | Cell adhesion molecules (CAMs) |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016021 | integral to membrane | NAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007165 | signal transduction | NAS | biological_process |
| GO:0042113 | B cell activation | IEA | biological_process |
| GO:0006952 | defense response | NAS | biological_process |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | IEA | cellular_component |
| GO:0042110 | T cell activation | NAS | biological_process |
| GO:0042104 | positive regulation of activated T cell proliferat | TAS | biological_process |
| GO:0045404 | positive regulation of interleukin-4 biosynthetic | IEA | biological_process |
| GO:0005102 | receptor binding | TAS | molecular_function |
| GO:0006972 | hyperosmotic response | NAS | biological_process |
| GO:0031295 | T cell costimulation | TAS | biological_process |