Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IBP3_HUMAN
Description:insulin-like growth factor binding protein 3 [Source:HGNC Symbol;Acc:5472]
Location:chr7 p12.3
Node attribute:PPI(source); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S194DYESQsTDTQNPhosphoSitePlus
S138APGNAsESEEDCSNK2A1HPRD
S140GNASEsEEDRSCK2a1-rsRegPhos
S140GNASEsEEDRSCK2a1RegPhos
S140GNASEsEEDRSCK2_groupphosphoELM; RegPhos
S140GNASEsEEDRSPhosphoSitePlus
S146GNASEsEEDRSCSNK2A1HPRD
S138APGNAsESEEDCK2a1-rsRegPhos
S138APGNAsESEEDPhosphoSitePlus
S138APGNAsESEEDCK2a1RegPhos
S140GNASEsEEDRSCSNK2A1HPRD
S138APGNAsESEEDCK2_groupphosphoELM; RegPhos
S207DTQNFsSESKRHPRD
Y246DKKGFyKKKQCThyroglobulin_1PhosphoSitePlus
S183GHAKDsQRYKVPhosphoSitePlus
S144APGNAsESEEDCSNK2A1HPRD
Y210KRETEyGPCRRPhosphoSitePlus
T7QRARPtLWAAAPhosphoSitePlus
S201DTQNFsSESKRHPRD

Dephosphorylation site
IBP3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000275521T7MHPIColorectal Cancer16959974
ENSP00000275521R252CHPIColorectal Cancer16959974
ENSP00000275521R185CBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000275521P238TCOSMICLung Cancer20668451
ENSP00000275521T7MSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000275521R252CSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000370473R191CBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
IBP3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IBP3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANIBP3_HUMANkinase -> substrateHPRD
IBP3_HUMANIGF1_HUMANotherKEGG
P53_HUMANIBP3_HUMANTF -> target geneKEGG
P53_HUMANIBP3_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer
hsa04115p53 signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043065positive regulation of apoptotic processIMPbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0008160protein tyrosine phosphatase activator activityIDAmolecular_function
GO:0001968fibronectin bindingIEAmolecular_function
GO:0045663positive regulation of myoblast differentiationIDAbiological_process
GO:0014912negative regulation of smooth muscle cell migratioIDAbiological_process
GO:0031994insulin-like growth factor I bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005576extracellular regionNAScellular_component
GO:0009968negative regulation of signal transductionNASbiological_process
GO:0044342type B pancreatic cell proliferationIEAbiological_process
GO:0043568positive regulation of insulin-like growth factor IEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005520insulin-like growth factor bindingIEAmolecular_function
GO:0005520insulin-like growth factor bindingNASmolecular_function
GO:0001933negative regulation of protein phosphorylationIDAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0008285negative regulation of cell proliferationIGIbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0046872metal ion bindingNASmolecular_function
GO:0010906regulation of glucose metabolic processIEAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0048662negative regulation of smooth muscle cell proliferIDAbiological_process
GO:0040008regulation of growthIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0016942insulin-like growth factor binding protein complexICcellular_component
GO:0001558regulation of cell growthIEAbiological_process


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