Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:I10R1_HUMAN
Description:interleukin 10 receptor, alpha [Source:HGNC Symbol;Acc:5964]
Location:chr11 q23.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y496ALAKGyLKQDPJAK1HPRD; RegPhos
Y496ALAKGyLKQDPPhosphoSitePlus
Y446VAFQGyLRQTRTyk2phosphoELM; RegPhos
Y446VAFQGyLRQTRJAK1HPRD; RegPhos
Y496ALAKGyLKQDPTyk2phosphoELM; RegPhos
Y446VAFQGyLRQTRPhosphoSitePlus
S268RKKLPsVLLFKPhosphoSitePlus

Dephosphorylation site
I10R1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000227752D538HBIOMARTBreast Cancer21930507, 21930502
ENSP00000227752E168DCOSMICOvarian Cancer21720365

Differential expressed protein
I10R1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
I10R1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
JAK1_HUMANI10R1_HUMANkinase -> substrateRegPhos
TYK2_HUMANI10R1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05169Epstein-Barr virus infection
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0004872receptor activityTASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0004920interleukin-10 receptor activityTASmolecular_function
GO:0004871signal transducer activityTASmolecular_function
GO:0016021integral to membraneIEAcellular_component