| UniProt/SwissProt ID: | HSP71_HUMAN |
| Description: | heat shock 70kDa protein 1B [Source:HGNC Symbol;Acc:5233] |
| Location: | chrHSCHR6_MHC_APD p2 |
| Node attribute: | PPI(source); gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y525 | QEAEKyKAEDE | phosphoELM | |
| Y611 | IISGLyQGAGG | HPRD; phosphoELM; SysPTM | |
| Y107 | KVQVSyKGETK | HPRD | |
| T222 | FEVKAtAGDTH | HPRD | |
| S106 | PKVQVsYKGET | HPRD | |
| S633 | KGGSGsGPTIE | HPRD | |
| S362 | RDLNKsINPDE | phosphoELM | |
| Y41 | RTTPSyVAFTD | phosphoELM | |
| S631 | GPKGGsGSGPT | HPRD; phosphoELM; SysPTM | |
| S608 | CNPIIsGLYQG | HPRD | |
| Y371 | DEAVAyGAAVQ | phosphoELM | |
| T636 | SGSGPtIEE | HPRD | |
| Dephosphorylation site |
| HSP71_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000364801 | S579* | COSMIC | Breast Cancer | 17932254 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000364801 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Down | 0.26 | 18646787 | ENSP00000364801 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 17902640 | ENSP00000364801 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Up | 2.4 | 17627933 | ENSP00000364801 | Oral Cancer | Normal vs. Cancer | tissue | Down | 0.36 | 19297561 | ENSP00000364801 | hepatitis B virus | Normal vs. Cancer | tissue | Up | 20 | 14654528 | ENSP00000364801 | hepatitis C virus | Normal vs. Cancer | tissue | Up | 20 | 14654528 | ENSP00000364801 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Up | 20 | 14654528 | ENSP00000364801 | Gastric Cancer | Normal vs. Cancer | tissue | Down | 0.31 | 19330469 | ENSP00000364801 | Oral Cancer | Normal vs. Cancer | tissue | Up | 2.3 | 19691830 | ENSP00000364801 | chronic myeloid leukemia | Treatment (Imatinib-sensitive vs. Imatinib-resistant) | cell line | Down | 20417730 | ENSP00000364801 | Neoplasms by Histologic Type | Cancer vs. Cancer (subtype) | tissue | Up | 2.3 | 16807943 | ENSP00000364801 | Neoplasms by Histologic Type | Cancer vs. Cancer (subtype) | tissue | Up | 2.9 | 16807943 | ENSP00000364801 | Testicular Cancer | Normal vs. Cancer | cell line | Down | 18489135 | ENSP00000364801 | Ovarian Cancer | Metastasis | cell line | Up | 17892554 | ENSP00000364801 | Ovarian Cancer | Treatment (chemotherapy-sensitive vs. chemotherapy-resistant) | tissue | Down | 0.22 | 19422301 | ENSP00000364801 | Gastric Cancer | Treatment (none vs. drug-resistant) | cell line | Up | 1.4 | 20625496 | ENSP00000364801 | Gastric Cancer | Normal vs. Cancer | tissue | Down | 0.67 | 15761955 |
| Hyperphosphorylation site |
| HSP71_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| HSP71_HUMAN | MK08_HUMAN | other | KEGG |
| SP1_HUMAN | HSP71_HUMAN | TF -> target gene | TRANSFAC |
| HSF1_HUMAN | HSP71_HUMAN | TF -> target gene | TRANSFAC |
| HSF2_HUMAN | HSP71_HUMAN | TF -> target gene | TRANSFAC |
| TBP_HUMAN | HSP71_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05169 | Epstein-Barr virus infection |
| hsa05164 | Influenza A |
| hsa05164 | Influenza A |
| hsa05162 | Measles |
| hsa04144 | Endocytosis |
| hsa05134 | Legionellosis |
| hsa04612 | Antigen processing and presentation |
| hsa05145 | Toxoplasmosis |
| hsa04612 | Antigen processing and presentation |
| hsa05162 | Measles |
| hsa04144 | Endocytosis |
| hsa05169 | Epstein-Barr virus infection |
| hsa03040 | Spliceosome |
| hsa05145 | Toxoplasmosis |
| hsa04010 | MAPK signaling pathway |
| hsa05134 | Legionellosis |
| hsa04141 | Protein processing in endoplasmic reticulum |
| hsa04141 | Protein processing in endoplasmic reticulum |
| hsa04010 | MAPK signaling pathway |
| hsa05020 | Prion diseases |
| hsa03040 | Spliceosome |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0045648 | positive regulation of erythrocyte differentiation | IMP | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0016071 | mRNA metabolic process | TAS | biological_process |
| GO:0016607 | nuclear speck | IDA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0090084 | negative regulation of inclusion body assembly | IDA | biological_process |
| GO:0044183 | protein binding involved in protein folding | IDA | molecular_function |
| GO:0005739 | mitochondrion | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0048471 | perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0005783 | endoplasmic reticulum | TAS | cellular_component |
| GO:0008180 | signalosome | IDA | cellular_component |
| GO:0042026 | protein refolding | IDA | biological_process |
| GO:0006402 | mRNA catabolic process | IDA | biological_process |
| GO:0047485 | protein N-terminus binding | IPI | molecular_function |
| GO:0051082 | unfolded protein binding | TAS | molecular_function |
| GO:0000902 | cell morphogenesis | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0030529 | ribonucleoprotein complex | IDA | cellular_component |
| GO:0031625 | ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0008285 | negative regulation of cell proliferation | IMP | biological_process |
| GO:0016235 | aggresome | IDA | cellular_component |
| GO:0016234 | inclusion body | IDA | cellular_component |
| GO:0043066 | negative regulation of apoptotic process | TAS | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0030308 | negative regulation of cell growth | IMP | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0006986 | response to unfolded protein | IDA | biological_process |