Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HLAG_HUMAN
Description:major histocompatibility complex, class I, G [Source:HGNC Symbol;Acc:4964]
Location:chrHSCHR6_MHC_MANN p
Node attribute:ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S167TAAQIsKRKCEMHC_IPhosphoSitePlus
T323LAAVVtGAAVASNO; TMPhosphoSitePlus

Dephosphorylation site
HLAG_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000353472T264ICOSMICOvarian Cancer21720365
ENSP00000353472D338YCOSMICOvarian Cancer21720365
ENSP00000353472R68KCOSMICSkin Cancer21984974
ENSP00000353472Q300PCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000405238Oral CancerNormal vs. CancertissueUp4.919297561

Hyperphosphorylation site
HLAG_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HLAG_HUMANKI2L4_HUMANligand -> receptorHPMR
HLAG_HUMANKLRD1_HUMANligand -> receptorHPMR
HLAG_HUMANLIRB1_HUMANligand -> receptorHPMR
IRF1_HUMANHLAG_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05416Viral myocarditis
hsa05330Allograft rejection
hsa04940Type I diabetes mellitus
hsa05320Autoimmune thyroid disease
hsa05168Herpes simplex infection
hsa04144Endocytosis
hsa05203Viral carcinogenesis
hsa05169Epstein-Barr virus infection
hsa04612Antigen processing and presentation
hsa05332Graft-versus-host disease
hsa05166HTLV-I infection
hsa04650Natural killer cell mediated cytotoxicity
hsa04514Cell adhesion molecules (CAMs)
hsa04145Phagosome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031901early endosome membraneTAScellular_component
GO:0005102receptor bindingIPImolecular_function
GO:0006955immune responseIEAbiological_process
GO:0045591positive regulation of regulatory T cell differentIMPbiological_process
GO:0002666positive regulation of T cell tolerance inductionIMPbiological_process
GO:0002474antigen processing and presentation of peptide antTASbiological_process
GO:0042612MHC class I protein complexIEAcellular_component
GO:0019882antigen processing and presentationIEAbiological_process
GO:0042803protein homodimerization activityNASmolecular_function
GO:0032735positive regulation of interleukin-12 productionIDAbiological_process
GO:0042590antigen processing and presentation of exogenous pTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0002767immune response-inhibiting cell surface receptor sIDAbiological_process
GO:0002479antigen processing and presentation of exogenous pTASbiological_process
GO:0071556integral to lumenal side of endoplasmic reticulum TAScellular_component
GO:0042130negative regulation of T cell proliferationIDAbiological_process
GO:0032393MHC class I receptor activityTASmolecular_function
GO:0000139Golgi membraneTAScellular_component
GO:0006968cellular defense responseTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0050776regulation of immune responseTASbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:2001199negative regulation of dendritic cell differentiatIDAbiological_process
GO:0060337type I interferon-mediated signaling pathwayTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0012507ER to Golgi transport vesicle membraneTAScellular_component
GO:0030670phagocytic vesicle membraneTAScellular_component
GO:0002480antigen processing and presentation of exogenous pTASbiological_process


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