Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KI2L4_HUMAN
Description:killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 [Source:HGNC Symbol;Acc:6332]
Location:chr19 q13.42
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S356ALMGSsRETTAPhosphoSitePlus
Y74PVPELyNRIFWPhosphoSitePlus
Y123MVTGLyEKPSLPhosphoSitePlus
S355QALMGsSRETTPhosphoSitePlus

Dephosphorylation site
KI2L4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000339634L13HTCGAOvarian Cancer21720365, 18772890
ENSP00000350088P126LBIOMARTBreast Cancer21930507, 21930502
ENSP00000339634P126LBIOMARTBreast Cancer21930507, 21930502
ENSP00000379588P31LBIOMARTBreast Cancer21930507, 21930502
ENSP00000350088R54SBIOMARTBreast Cancer21930507, 21930502
ENSP00000339634R54SBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
KI2L4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KI2L4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HLAG_HUMANKI2L4_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04612Antigen processing and presentation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionTASbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0005886plasma membraneTAScellular_component
GO:0006968cellular defense responseTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004888transmembrane signaling receptor activityTASmolecular_function
GO:0050776regulation of immune responseTASbiological_process


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