Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LIRB1_HUMAN
Description:leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 [Source:HGNC Symbol;Acc:6605]
Location:chrHSCHR19LRC_PGF1_C
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T613APQDVtYAQLHPhosphoSitePlus
Y614PQDVTyAQLHSPhosphoSitePlus
Y533QEENLyAAVKHPhosphoSitePlus
Y378YQSQKyQAEFPigPhosphoSitePlus
Y562PQAVTyAEVKHPhosphoSitePlus
S580MASPPsPLSGEHPRD
S579MASPPsPLSGEPhosphoSitePlus; HPRD
S581MASPPsPLSGEHPRD
Y644AVPSIyATLAIPhosphoSitePlus

Dephosphorylation site
LIRB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000379614E564KBIOMARTBreast Cancer21930507, 21930502
ENSP00000379622R370SCOSMICHead and Neck Cancer21798893
ENSP00000379622R368PBIOMARTBreast Cancer21930507, 21930502
ENSP00000379622P636HCOSMICHead and Neck Cancer21798893
ENSP00000379622S420LCOSMICMelanoma21499247
ENSP00000379622S606TCOSMICHead and Neck Cancer21798893
ENSP00000315997P579TBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000379608D365NTCGAOvarian Cancer21720365, 18772890
ENSP00000315997P580TBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000315997R368PBIOMARTBreast Cancer21930507, 21930502
ENSP00000379622R59CCOSMICHead and Neck Cancer21798893
ENSP00000379622E564KBIOMARTBreast Cancer21930507, 21930502
ENSP00000379622D365NCOSMICOvarian Cancer21720365
ENSP00000379622E54KCOSMICHead and Neck Cancer21798893
ENSP00000315997D365NTCGAOvarian Cancer21720365, 18772890
ENSP00000315997E566KBIOMARTBreast Cancer21930507, 21930502
ENSP00000405243R368PBIOMARTBreast Cancer21930507, 21930502
ENSP00000405243E564KBIOMARTBreast Cancer21930507, 21930502
ENSP00000379614R368PBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
LIRB1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LIRB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HLAG_HUMANLIRB1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04380Osteoclast differentiation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0035548negative regulation of interferon-beta secretionIDAbiological_process
GO:0001915negative regulation of T cell mediated cytotoxicitIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045806negative regulation of endocytosisIDAbiological_process
GO:0097028dendritic cell differentiationIEPbiological_process
GO:0050776regulation of immune responseTASbiological_process
GO:0045919positive regulation of cytolysisIDAbiological_process
GO:0042536negative regulation of tumor necrosis factor biosyIDAbiological_process
GO:2001186negative regulation of CD8-positive, alpha-beta T IDAbiological_process
GO:0051926negative regulation of calcium ion transportIDAbiological_process
GO:0002774Fc receptor mediated inhibitory signaling pathwayIDAbiological_process
GO:0002767immune response-inhibiting cell surface receptor sNASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0051607defense response to virusIDAbiological_process
GO:0010628positive regulation of gene expressionIDAbiological_process
GO:0042169SH2 domain bindingIDAmolecular_function
GO:0007165signal transductionIDAbiological_process
GO:2001202negative regulation of transforming growth factor-IDAbiological_process
GO:0042288MHC class I protein bindingIPImolecular_function
GO:0008157protein phosphatase 1 bindingIPImolecular_function
GO:2001189negative regulation of T cell activation via T celIDAbiological_process
GO:2001180negative regulation of interleukin-10 secretionIDAbiological_process
GO:2001193positive regulation of gamma-delta T cell activatiIDAbiological_process
GO:0009615response to virusIDAbiological_process
GO:2000669negative regulation of dendritic cell apoptotic prIDAbiological_process
GO:0009897external side of plasma membraneIDAcellular_component
GO:0032945negative regulation of mononuclear cell proliferatIDAbiological_process
GO:0002309T cell proliferation involved in immune responseIDAbiological_process
GO:0032689negative regulation of interferon-gamma productionIDAbiological_process
GO:0030109HLA-B specific inhibitory MHC class I receptor actIDAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0032393MHC class I receptor activityIDAmolecular_function
GO:0042803protein homodimerization activityIPImolecular_function
GO:0045953negative regulation of natural killer cell mediateIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyNASbiological_process
GO:2001199negative regulation of dendritic cell differentiatIMPbiological_process
GO:2001183negative regulation of interleukin-12 secretionIDAbiological_process
GO:0002740negative regulation of cytokine secretion involvedIDAbiological_process
GO:0030107HLA-A specific inhibitory MHC class I receptor actIDAmolecular_function
GO:0045786negative regulation of cell cycleIDAbiological_process
GO:0045077negative regulation of interferon-gamma biosynthetIDAbiological_process
GO:2001205negative regulation of osteoclast developmentIDAbiological_process
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0032609interferon-gamma productionIDAbiological_process
GO:0046636negative regulation of alpha-beta T cell activatioIDAbiological_process
GO:0072643interferon-gamma secretionIDAbiological_process
GO:0031623receptor internalizationTASbiological_process
GO:0014063negative regulation of serotonin secretionIDAbiological_process
GO:0002230positive regulation of defense response to virus bIDAbiological_process
GO:0071222cellular response to lipopolysaccharideIEPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0042130negative regulation of T cell proliferationIDAbiological_process