Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HDAC1_HUMAN
Description:histone deacetylase 1 [Source:HGNC Symbol;Acc:4852]
Location:chr1 p35.1
Node attribute:deacetylation(source); desumoylation(target); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S423EEFSDsEEEGECK2_alphaphosphoELM
S434GGRKNsSNFKKSDA1PhosphoSitePlus
S423EEFSDsEEEGECK2a2RegPhos
S423EEFSDsEEEGECK2a1RegPhos
Y48LNYGLyRKMEIHist_deacetylPhosphoSitePlus
S421CEEEFsDSEEECK2a1RegPhos; SysPTM
S421CEEEFsDSEEECK2a2RegPhos; SysPTM
T38HRIRMtHNLLLHist_deacetylPhosphoSitePlus
S406PDKRIsICSSDHPRD; phosphoELM
S423EEFSDsEEEGESDA1PhosphoSitePlus
Y226YYAVNyPLRDGHPRD
S423EEFSDsEEEGECSNK2A2HPRD
S423EEFSDsEEEGECSNK2A1HPRD
S423EEFSDsEEEGECK2a1-rsRegPhos
S409RISICsSDKRIHPRD; phosphoELM
Y221AGKGKyYAVNYHist_deacetylPhosphoSitePlus
Y87DNMSEySKQMQHist_deacetylPhosphoSitePlus
S421CEEEFsDSEEECK2_alphaphosphoELM; SysPTM
S421CEEEFsDSEEECK2a1(CK2 alphaRegPhos; SysPTM
Y336NDYFEyFGPDFPhosphoSitePlus
S421CEEEFsDSEEECK2_groupphosphoELM; RegPhos; SysPTM
S393AIPEEsGDEDESDA1PhosphoSitePlus; SysPTM
S290VEFVKsFNLPMHist_deacetylPhosphoSitePlus
S423EEFSDsEEEGEphosphoELM
S421CEEEFsDSEEEHPRD; phosphoELM; SysPTM
T445AKRVKtEDEKESDA1PhosphoSitePlus
Y45NLLLNyGLYRKHist_deacetylPhosphoSitePlus
S410ISICSsDKRIAHPRD; phosphoELM
Y333LPYNDyFEYFGPhosphoSitePlus
S421CEEEFsDSEEESDA1PhosphoSitePlus; SysPTM
S423EEFSDsEEEGECK2_groupphosphoELM; RegPhos
Y237IDDESyEAIFKHPRD
Y204HKYGEyFPGTGHist_deacetylPhosphoSitePlus
S421CEEEFsDSEEECK2a1-rsRegPhos; SysPTM
Y222GKGKYyAVNYPHPRD
S393AIPEEsGDEDEHPRD; phosphoELM; RegPhos; SysPTM
S435GRKNSsNFKKASDA1PhosphoSitePlus
S423EEFSDsEEEGECK2a1(CK2 alphaRegPhos
Y226YYAVNyPLRDGHist_deacetylPhosphoSitePlus
S421CEEEFsDSEEECSNK2A1HPRD; SysPTM
S421CEEEFsDSEEECSNK2A2HPRD; SysPTM
Y221AGKGKyYAVNYHPRD; RegPhos

Dephosphorylation site
HDAC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000362649G25ATCGAOvarian Cancer21720365, 18772890
ENSP00000362649R431CCOSMICLung Cancer20668451
ENSP00000362649G25ACOSMICOvarian Cancer21720365
ENSP00000362649E398KBIOMARTBreast Cancer21930507, 21930502
ENSP00000362649L370FCOSMICSkin Cancer21984974
ENSP00000362649R365QCOSMICBreast Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000362649Breast CancerNormal vs. Cancercell lineUp1320052998
ENSP00000362649Breast CancerNormal vs. Cancercell lineUp1120052998
ENSP00000362649Breast CancerMetastasiscell lineDown0.9320052998

Hyperphosphorylation site
HDAC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK22_HUMANHDAC1_HUMANkinase -> substrateHPRD
CSK21_HUMANHDAC1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANHDAC1_HUMANkinase -> substrateRegPhos
SENP1_HUMANHDAC1_HUMANdesumoylationNetPath
HDAC1_HUMANANDR_HUMANdeacetylationNetPath
HDAC1_HUMANRBPJL_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer
hsa04110Cell cycle
hsa05034Alcoholism
hsa05200Pathways in cancer
hsa05031Amphetamine addiction
hsa05220Chronic myeloid leukemia
hsa05016Huntington's disease
hsa05169Epstein-Barr virus infection
hsa04330Notch signaling pathway
hsa05203Viral carcinogenesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0010467gene expressionTASbiological_process
GO:0032041NAD-dependent histone deacetylase activity (H3-K14IEAmolecular_function
GO:0000118histone deacetylase complexTAScellular_component
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0042826histone deacetylase bindingIPImolecular_function
GO:0008134transcription factor bindingTASmolecular_function
GO:0016581NuRD complexIDAcellular_component
GO:0006476protein deacetylationIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0043066negative regulation of apoptotic processISSbiological_process
GO:0070933histone H4 deacetylationIDAbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0060789hair follicle placode formationISSbiological_process
GO:0004407histone deacetylase activityIEAmolecular_function
GO:0046970NAD-dependent histone deacetylase activity (H4-K16IEAmolecular_function
GO:0000790nuclear chromatinIDAcellular_component
GO:0010870positive regulation of receptor biosynthetic proceIMPbiological_process
GO:0046969NAD-dependent histone deacetylase activity (H3-K9 IEAmolecular_function
GO:0061198fungiform papilla formationISSbiological_process
GO:0001106RNA polymerase II transcription corepressor activiIDAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0042475odontogenesis of dentin-containing toothISSbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0060766negative regulation of androgen receptor signalingIDAbiological_process
GO:0042733embryonic digit morphogenesisISSbiological_process
GO:0061029eyelid development in camera-type eyeISSbiological_process
GO:0016575histone deacetylationIMPbiological_process
GO:0097372NAD-dependent histone deacetylase activity (H3-K18IEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0019899enzyme bindingIPImolecular_function
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0033613activating transcription factor bindingIPImolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0000122negative regulation of transcription from RNA polyIMPbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0006338chromatin remodelingICbiological_process
GO:0005654nucleoplasmIDAcellular_component
GO:0001047core promoter bindingIDAmolecular_function
GO:0045786negative regulation of cell cycleTASbiological_process
GO:0005829cytosolIDAcellular_component
GO:0033558protein deacetylase activityIDAmolecular_function
GO:0070932histone H3 deacetylationIDAbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0001103RNA polymerase II repressing transcription factor IPImolecular_function
GO:0016580Sin3 complexIDAcellular_component
GO:0043922negative regulation by host of viral transcriptionIMPbiological_process
GO:0016568chromatin modificationTASbiological_process
GO:0009913epidermal cell differentiationISSbiological_process