| UniProt/SwissProt ID: | HBA_HUMAN |
| Description: | hemoglobin, alpha 1 [Source:HGNC Symbol;Acc:4823] |
| Location: | chr16 p13.3 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T9 | SPADKtNVKAA | HPRD | |
| S4 | ADKT | HPRD | |
| S53 | DLSHGsAQVKG | Globin | PhosphoSitePlus |
| T40 | LSFPTtKTYFP | Globin | PhosphoSitePlus |
| S36 | ERMFLsFPTTK | Globin | PhosphoSitePlus |
| Y25 | AHAGEyGAEAL | Globin | PhosphoSitePlus |
| T9 | SPADKtNVKAA | Globin | PhosphoSitePlus |
| S53 | DLSHGsAQVKG | HPRD | |
| T109 | HCLLVtLAAHL | Globin | PhosphoSitePlus |
| Y25 | AHAGEyGAEAL | HPRD; phosphoELM | |
| S139 | STVLTsKYR__ | PhosphoSitePlus | |
| Y141 | VLTSKyR____ | PhosphoSitePlus | |
| S4 | __MVLsPADKT | PhosphoSitePlus | |
| Y43 | PTTKTyFPHFD | HPRD; phosphoELM | |
| Y43 | PTTKTyFPHFD | Globin | PhosphoSitePlus |
| T42 | FPTTKtYFPHF | Globin | PhosphoSitePlus |
| Dephosphorylation site |
| HBA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| HBA_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000322421 | hepatitis B virus | Normal vs. Cancer | tissue | Up | 3.4 | 14726492 | ENSP00000322421 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 17902640 | ENSP00000322421 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Down | 0.27 | 17627933 | ENSP00000322421 | Oral Cancer | Normal vs. Cancer | tissue | Down | 0.13 | 19691830 | ENSP00000322421 | Pancreatic Cancer | Normal vs. Cancer | tissue | Down | 0.32 | 16230073 |
| Hyperphosphorylation site |
| HBA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SP1_HUMAN | HBA_HUMAN | TF -> target gene | TRANSFAC |
| NFIC_HUMAN | HBA_HUMAN | TF -> target gene | TRANSFAC |
| Q15552_HUMAN | HBA_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| HBA_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005506 | iron ion binding | IEA | molecular_function |
| GO:0015671 | oxygen transport | TAS | biological_process |
| GO:0015701 | bicarbonate transport | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004601 | peroxidase activity | IDA | molecular_function |
| GO:0005344 | oxygen transporter activity | IEA | molecular_function |
| GO:0031720 | haptoglobin binding | IDA | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0019825 | oxygen binding | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0010942 | positive regulation of cell death | IDA | biological_process |
| GO:0051291 | protein heterooligomerization | IDA | biological_process |
| GO:0022627 | cytosolic small ribosomal subunit | IDA | cellular_component |
| GO:0031838 | haptoglobin-hemoglobin complex | IDA | cellular_component |
| GO:0042542 | response to hydrogen peroxide | IDA | biological_process |
| GO:0042744 | hydrogen peroxide catabolic process | IDA | biological_process |
| GO:0020037 | heme binding | IEA | molecular_function |
| GO:0005833 | hemoglobin complex | IEA | cellular_component |