Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HASP_HUMAN
Description:germ cell associated 2 (haspin) [Source:HGNC Symbol;Acc:19682]
Location:chr17 p13.2
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T112PSLTVtPRRLGPhosphoSitePlus
S108LRARPsLTVTPPhosphoSitePlus
T191VISIGtSACLVPhosphoSitePlus
S93PKDRPsLTVTPPhosphoSitePlus; HPRD; phosphoELM
S216SLDRAsLPCSQPhosphoSitePlus; HPRD
T289PGLSStGKRRAPhosphoSitePlus; HPRD
S220ASLPCsQEEATPhosphoSitePlus; HPRD; phosphoELM
S58SIGDPsQSDDPPhosphoSitePlus
S147DSGRLsPDLSVPhosphoSitePlus; HPRD; phosphoELM
S288GPGLSsTGKRRPhosphoSitePlus; HPRD
T373PTQDLtPLQNVPhosphoSitePlus
T253LMNSGtPEDSEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T97PSLTVtPKRWKPhosphoSitePlus; HPRD; phosphoELM
S287EGPGLsSTGKRPhosphoSitePlus; HPRD
S340RSSRKsKHQEAPhosphoSitePlus
T128PQKCStPCGPLPhosphoSitePlus
S143FPSRDsGRLSPPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
HASP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000325290D365HBIOMARTGastric Cancer21930507, 21930502

Differential expressed protein
HASP_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HASP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HASP_HUMANAIRE_HUMANkinase -> substrateRobert H Newman (2013)
HASP_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
HASP_HUMANLZTS1_HUMANkinase -> substrateRobert H Newman (2013)
HASP_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
HASP_HUMANPLK1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
HASP_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0005819spindleIDAcellular_component
GO:0090231regulation of spindle checkpointIMPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0031965nuclear membraneIDAcellular_component
GO:0005524ATP bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:2000751histone H3-T3 phosphorylation involved in chromosoIMPbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0005694chromosomeIEAcellular_component
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0007049cell cycleIEAbiological_process
GO:0007064mitotic sister chromatid cohesionIMPbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0005813centrosomeIDAcellular_component
GO:0071459protein localization to chromosome, centromeric reIMPbiological_process
GO:0072354histone kinase activity (H3-T3 specific)IMPmolecular_function
GO:0003677DNA bindingIEAmolecular_function


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