Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:H2AX_HUMAN
Description:H2A histone family, member X [Source:HGNC Symbol;Acc:4739]
Location:chr11 q23.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T137GGKKAtQASQEPhosphoSitePlus; RegPhos
T121LLPKKtSATVGPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S2RGKTHPRD
S2MSGRGkTRegPhos
S140KATQAsQEYATRRegPhos
S140KATQAsQEYATMRegPhos
T137GGKKAtQASQHPRD
S140KATQAsQATMHPRD; phosphoELM
T124KKTSAtVGPKAPhosphoSitePlus; phosphoELM; RegPhos
S140KATQAsQEY__PhosphoSitePlus
Y40LRKGHyAERVGHistonePhosphoSitePlus
T102LLGGVtIAQGGPhosphoSitePlus
S140KATQAsQphosphoELM
S140KATQAsQEYDNAPKRegPhos
S122LPKKTsATVGPPhosphoSitePlus; HPRD
Y143QASQEy_____PhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S140GKKATQAsQEYPPP1CAHPRD

Mutation site
H2AX_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000364310Breast CancerNormal vs. CancertissueUp0.6720739354
ENSP00000364310Breast CancerNormal vs. CancertissueUp0.6720739354

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S140GKKATQAsQEY____testicular cancer15846060PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ATR_HUMANH2AX_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANH2AX_HUMANkinase -> substrateRegPhos
ATM_HUMANH2AX_HUMANkinase -> substrateHPRD; RegPhos
PP1A_HUMANH2AX_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05322Systemic lupus erythematosus
hsa05034Alcoholism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006281DNA repairTASbiological_process
GO:0000790nuclear chromatinIEAcellular_component
GO:0045739positive regulation of DNA repairNASbiological_process
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0007283spermatogenesisIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005657replication forkIEAcellular_component
GO:0007126meiosisIEAbiological_process
GO:0006281DNA repairIEAbiological_process
GO:0006334nucleosome assemblyNASbiological_process
GO:0000724double-strand break repair via homologous recombinIEAbiological_process
GO:0000785chromatinIEAcellular_component
GO:0000786nucleosomeNAScellular_component
GO:0005622intracellularIEAcellular_component
GO:0042393histone bindingIPImolecular_function
GO:0005694chromosomeIEAcellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0001673male germ cell nucleusIEAcellular_component
GO:0003677DNA bindingNASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006302double-strand break repairNASbiological_process
GO:0001741XY bodyIEAcellular_component
GO:0019899enzyme bindingIPImolecular_function
GO:0000724double-strand break repair via homologous recombinTASbiological_process
GO:0010212response to ionizing radiationNASbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0000077DNA damage checkpointIDAbiological_process
GO:0000794condensed nuclear chromosomeIEAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0000781chromosome, telomeric regionIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0003684damaged DNA bindingIEAmolecular_function


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