Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GRM1_HUMAN
Description:glutamate receptor, metabotropic 1 [Source:HGNC Symbol;Acc:4593]
Location:chr6 q24.3
Node attribute:substrate; GPCR; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T695KKKICtRKPRFPKC_groupphosphoELM; RegPhos
T695KKKICtRKPRFPKCaRegPhos
T620VLYRDtPVVKS7tm_3PhosphoSitePlus
T677YSALVtKTNRI7tm_3; TMPhosphoSitePlus
T188IAYSAtSIDLSANF_receptorPhosphoSitePlus
Y672SSAMCySALVTRegPhos
T871PCRSNtFLNIFPhosphoSitePlus
S869KLPCRsNTFLNPhosphoSitePlus
Y632SRELCyIILAG7tm_3; TMPhosphoSitePlus
Y1111LQEYVyEHEREPhosphoSitePlus
T695KKKICtRKPRFPRKCAHPRD
Y1109KLLQEyVYEHEPhosphoSitePlus
Y672SSAMCySALVT7tm_3; TMPhosphoSitePlus
T679ALVTKtNRIAR7tm_3; TMPhosphoSitePlus

Dephosphorylation site
GRM1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000282753A229SCOSMICOvarian Cancer21720365
ENSP00000282753R375GCOSMICLung Cancer20668451
ENSP00000282753R696WHPIColorectal Cancer16959974
ENSP00000282753W224CTCGAOvarian Cancer21720365, 18772890
ENSP00000425599R297*BIOMARTBreast Cancer21930507, 21930502
ENSP00000282753R967HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000282753P1148LCOSMICIntestines Cancer17932254
ENSP00000282753G688VCOSMICLung Cancer20668451
ENSP00000282753D44ECOSMICLung Cancer20668451
ENSP00000282753E1006KCOSMICSkin Cancer21984974
ENSP00000282753R967HCOSMICCentral Nervous System Neoplasms18772890
ENSP00000282753S626CCOSMICCentral Nervous System Neoplasms18772890
ENSP00000282753Q706*COSMICHead and Neck Cancer21984974
ENSP00000282753A229STCGAOvarian Cancer21720365, 18772890
ENSP00000282753R78SCOSMICOvarian Cancer21720365
ENSP00000282753P444LCOSMICHead and Neck Cancer21798893
ENSP00000282753S33LCOSMICHead and Neck Cancer21984974
ENSP00000282753T647PBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000282753R684CCOSMICCentral Nervous System Neoplasms18772396
ENSP00000282753G396VCOSMICLung Cancer20668451
ENSP00000282753C547FCOSMICSkin Cancer21984974
ENSP00000282753D1096NCOSMICOvarian Cancer21720365
ENSP00000282753W224CCOSMICOvarian Cancer21720365
ENSP00000376119A184TBIOMARTchronic lymphocytic leukemia21930507, 21930502
ENSP00000354896S626CTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000282753S626CTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000424095R297*BIOMARTBreast Cancer21930507, 21930502
ENSP00000354896R967HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000354896W224CTCGAOvarian Cancer21720365, 18772890
ENSP00000282753R71KCOSMICSkin Cancer21984974
ENSP00000282753A168VCOSMICLung Cancer20668451
ENSP00000376119R297*BIOMARTBreast Cancer21930507, 21930502
ENSP00000282753E386*COSMICLung Cancer20668451
ENSP00000282753R297*BIOMARTBreast Cancer21930507, 21930502
ENSP00000354896R684CBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000354896R297*BIOMARTBreast Cancer21930507, 21930502
ENSP00000354896R696WBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000354896A229STCGAOvarian Cancer21720365, 18772890
ENSP00000282753R696WSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000282753D87HCOSMICOvarian Cancer21720365

Differential expressed protein
GRM1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GRM1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GRM1_HUMANGNAQ_HUMANGPCR -> GproteingpDB
GRM1_HUMANGNA11_HUMANGPCR -> GproteingpDB
ZAGL2_HUMANGRM1_HUMANkinase -> substrateRegPhos
KPCA_HUMANGRM1_HUMANkinase -> substrateHPRD
GLHA_HUMANGRM1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa05016Huntington's disease
hsa04723Retrograde endocannabinoid signaling
hsa04020Calcium signaling pathway
hsa04730Long-term depression
hsa04540Gap junction
hsa04720Long-term potentiation
hsa04724Glutamatergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000186activation of MAPKK activityIEAbiological_process
GO:0071257cellular response to electrical stimulusIEAbiological_process
GO:0004930G-protein coupled receptor activityTASmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0000187activation of MAPK activityIEAbiological_process
GO:0019233sensory perception of painIEAbiological_process
GO:0007626locomotory behaviorIEAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0008066glutamate receptor activityTASmolecular_function
GO:0051930regulation of sensory perception of painIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0043005neuron projectionIEAcellular_component
GO:0043408regulation of MAPK cascadeIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0007268synaptic transmissionTASbiological_process
GO:0014069postsynaptic densityIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005886plasma membraneTAScellular_component