Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GRIA1_HUMAN
Description:Glutamate receptor 1 [Source:UniProtKB/Swiss-Prot;Acc:P42261]
Location:chr5 q33.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S863TLPRNsGAGASPRKACAHPRD
Y226KNGIGyHYILAANF_receptorPhosphoSitePlus
S567PYEWHsEEFEESBP_bac_3; Lig_chanPhosphoSitePlus
S849LIPQQsINEAICaMK2_groupRegPhos
Y294TSALTyDGVKVANF_receptorPhosphoSitePlus
S849LIPQQsINEAIPhosphoSitePlus; RegPhos
S849LIPQQsINEAIPKC_groupphosphoELM; RegPhos
S863TLPRNsGAGASPhosphoSitePlus; phosphoELM; RegPhos
S849LIPQQsINEAICaM-KII_groupphosphoELM
S645VERMVsPIESARegPhos
S849LIPQQsINEAIPRKCAHPRD
Y228GIGYHyILANLANF_receptorPhosphoSitePlus
S849LIPQQsINEAIPKCaRegPhos
S863TLPRNsGAGASPKA_groupphosphoELM; RegPhos
S849LIPQQsINEAICaMK2gRegPhos
T393FVPAAtDAQAGHPRD
S849LIPQQsINEAICAMK2GHPRD
T350RFEGLtGNVQFANF_receptor; DUF3616PhosphoSitePlus
S754ATPKGsALRNPSBP_bac_3; Lig_chanPhosphoSitePlus
S645VERMVsPIESACAMK2GHPRD
S645VERMVsPIESACaMK2gRegPhos
S836KSRSEsKRMKGPhosphoSitePlus; phosphoELM
S710IRVRKsKGKYARegPhos
S849LIPQQsINEAIPKC_alphaphosphoELM
S832EFCYKsRSESKPhosphoSitePlus
S863TLPRNsGAGASPKACaRegPhos
S834CYKSRsESKRMPhosphoSitePlus; phosphoELM

Dephosphorylation site
GRIA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000285900A867SCOSMICOvarian Cancer21720365
ENSP00000285900G788SCOSMICHead and Neck Cancer21798893
ENSP00000285900A867STCGAOvarian Cancer21720365, 18772890
ENSP00000285900P521TBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000285900D774EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000285900D163YBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000339343G818EBIOMARTMelanoma21930507, 21930502
ENSP00000285900G818ECOSMICMelanoma20016485

Differential expressed protein
GRIA1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GRIA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANGRIA1_HUMANkinase -> substrateHPRD
KCC2G_HUMANGRIA1_HUMANkinase -> substrateHPRD
KCC4_HUMANGRIA1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANGRIA1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05031Amphetamine addiction
hsa04724Glutamatergic synapse
hsa04730Long-term depression
hsa04723Retrograde endocannabinoid signaling
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa04080Neuroactive ligand-receptor interaction
hsa04728Dopaminergic synapse
hsa04720Long-term potentiation
hsa05033Nicotine addiction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032590dendrite membraneIEAcellular_component
GO:0014069postsynaptic densityISScellular_component
GO:0030054cell junctionIEAcellular_component
GO:0006810transportIEAbiological_process
GO:0032281alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropioniISScellular_component
GO:0004970ionotropic glutamate receptor activityIEAmolecular_function
GO:0007616long-term memoryIEAbiological_process
GO:0030425dendriteISScellular_component
GO:0016020membraneIEAcellular_component
GO:0008066glutamate receptor activityTASmolecular_function
GO:0005234extracellular-glutamate-gated ion channel activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0044309neuron spineISScellular_component
GO:0004971alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionIDAmolecular_function
GO:0015277kainate selective glutamate receptor activityTASmolecular_function
GO:0030666endocytic vesicle membraneTAScellular_component
GO:0031623receptor internalizationIEAbiological_process
GO:0009986cell surfaceISScellular_component
GO:0030288outer membrane-bounded periplasmic spaceIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0043025neuronal cell bodyISScellular_component
GO:0005215transporter activityIEAmolecular_function
GO:0030165PDZ domain bindingISSmolecular_function
GO:0007268synaptic transmissionTASbiological_process
GO:0045211postsynaptic membraneIEAcellular_component
GO:0043197dendritic spineISScellular_component
GO:0005886plasma membraneTAScellular_component


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