UniProt/SwissProt ID: | FZR_HUMAN |
Description: | fizzy/cell division cycle 20 related 1 (Drosophila) [Source:HGNC Symbol;Acc:24824] |
Location: | chr19 p13.3 |
Node attribute: | PPI(source); substrate; PPI(target) |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
S40 | SSPVSsPSKHG | PhosphoSitePlus; HPRD; phosphoELM | |
S346 | NHSSLsPVQQY | WD40 | PhosphoSitePlus |
S163 | QKLLRsPRKPT | PhosphoSitePlus | |
S137 | LSTKRsSPDDG | PhosphoSitePlus; HPRD; phosphoELM | |
S163 | QKLLRsPRKPT | CDK_group | phosphoELM; RegPhos |
S151 | SPYSLsPVSNK | CDK_group | phosphoELM; RegPhos |
T300 | QRDIRtPPLQS | PhosphoSitePlus | |
Y91 | KDGLAySALLK | PhosphoSitePlus; RegPhos | |
S146 | DGNDVsPYSLS | PhosphoSitePlus; HPRD; phosphoELM | |
S154 | SLSPVsNKSQK | HPRD; phosphoELM | |
T121 | RLQPStPEKKG | PhosphoSitePlus | |
S72 | NEKSPsQNRKA | PhosphoSitePlus; phosphoELM | |
T30 | TEMRRtLTPAS | HPRD | |
S92 | DGLAYsALLKN | PhosphoSitePlus; RegPhos | |
S42 | PVSSPsKHGDR | PhosphoSitePlus; HPRD | |
S138 | STKRSsPDDGN | PhosphoSitePlus; HPRD; phosphoELM | |
S149 | DVSPYsLSPVS | HPRD | |
S120 | RRLQPsTPEKK | PhosphoSitePlus | |
S343 | LVWNHsSLSPV | PhosphoSitePlus | |
S39 | ASSPVsSPSKH | HPRD | |
S35 | TLTPAsSPVSS | PhosphoSitePlus | |
S36 | LTPASsPVSSP | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
S131 | GLFTYsLSTKR | PhosphoSitePlus | |
S151 | SPYSLsPVSNK | PhosphoSitePlus; phosphoELM; RegPhos | |
S163 | QKLLRsPRKPT | CDK2 | HPRD; RegPhos |
S70 | NENEKsPSQNR | PhosphoSitePlus; phosphoELM | |
T32 | MRRTLtPASSP | PhosphoSitePlus; HPRD; phosphoELM | |
S151 | SPYSLsPVSNK | CDK2 | HPRD; RegPhos |
Y5 | _MDQDyERRLL | PhosphoSitePlus | |
Dephosphorylation site |
FZR_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000410369 | Q350L | COSMIC | Head and Neck Cancer | 21798893 |
ENSP00000410369 | Q401* | COSMIC | Renal Cancer | 21248752 |
ENSP00000410369 | V253A | COSMIC | Lung Cancer | |
ENSP00000410369 | R493Q | COSMIC | Head and Neck Cancer | 21798893 |
Differential expressed protein |
FZR_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
FZR_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
ZAGL2_HUMAN | FZR_HUMAN | kinase -> substrate | RegPhos |
CDK2_HUMAN | FZR_HUMAN | kinase -> substrate | RegPhos |
GSK3B_HUMAN | FZR_HUMAN | kinase -> substrate | HPRD; RegPhos |
CSK21_HUMAN | FZR_HUMAN | kinase -> substrate | HPRD |
FZR_HUMAN | FZR_HUMAN | other | KEGG |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa04914 | Progesterone-mediated oocyte maturation |
hsa04120 | Ubiquitin mediated proteolysis |
hsa04110 | Cell cycle |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0070979 | protein K11-linked ubiquitination | TAS | biological_process |
GO:0070306 | lens fiber cell differentiation | IEA | biological_process |
GO:0051488 | activation of anaphase-promoting complex activity | IDA | biological_process |
GO:0031965 | nuclear membrane | IDA | cellular_component |
GO:0005680 | anaphase-promoting complex | IDA | cellular_component |
GO:0005634 | nucleus | IDA | cellular_component |
GO:0000278 | mitotic cell cycle | TAS | biological_process |
GO:0031572 | G2/M transition DNA damage checkpoint | IDA | biological_process |
GO:0045732 | positive regulation of protein catabolic process | IGI | biological_process |
GO:0090344 | negative regulation of cell aging | IEA | biological_process |
GO:0005515 | protein binding | IEA | molecular_function |
GO:0007067 | mitosis | IEA | biological_process |
GO:0005829 | cytosol | TAS | cellular_component |
GO:0051301 | cell division | IEA | biological_process |
GO:0000084 | S phase of mitotic cell cycle | TAS | biological_process |
GO:0005654 | nucleoplasm | TAS | cellular_component |
GO:0040020 | regulation of meiosis | IEA | biological_process |
GO:0031145 | anaphase-promoting complex-dependent proteasomal u | IDA | biological_process |
GO:0008284 | positive regulation of cell proliferation | IEA | biological_process |
GO:0006281 | DNA repair | IEA | biological_process |
GO:0051439 | regulation of ubiquitin-protein ligase activity in | TAS | biological_process |
GO:0051436 | negative regulation of ubiquitin-protein ligase ac | TAS | biological_process |
GO:0005515 | protein binding | IPI | molecular_function |
GO:0051437 | positive regulation of ubiquitin-protein ligase ac | TAS | biological_process |