Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FOXO3_HUMAN
Description:forkhead box O3 [Source:HGNC Symbol;Acc:3821]
Location:chr6 q21
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S209AGWKNsIRHNLMST1(STK4RegPhos
S209AGWKNsIRHNLFork_headPhosphoSitePlus
S286ADDSPsQLSKWPhosphoSitePlus; HPRD
S280QTAPEsADDSPPhosphoSitePlus; HPRD; phosphoELM
S318TNSNAsTVSGRPhosphoSitePlus; phosphoELM; RegPhos
S588LSDSLsGSSLYPhosphoSitePlus
T32RPRSCtWPLQRPKB_groupphosphoELM
S289SPSQLsKWPGSPhosphoSitePlus; HPRD
S555LSNSVsNMGLSPhosphoSitePlus
S7APLSHPRD
S30QSRPRsCTWPLPhosphoSitePlus
S421YTTKGsGLGSPPhosphoSitePlus; phosphoELM
Y184TLSQIyEWMVRFork_headPhosphoSitePlus
S315RSRTNsNASTVSGK1HPRD; RegPhos
S243PDGGKsGKAPRFork_headPhosphoSitePlus
S253RRRAVsMDNSNAKT1HPRD; RegPhos
S43PELQAsPAKPSPhosphoSitePlus
S231EGTGKsSWWIIFork_headPhosphoSitePlus
S232GTGKSsWWIINFork_headPhosphoSitePlus
T319NSNAStVSGRLPhosphoSitePlus
S294SKWPGsPTSRSPhosphoSitePlus
S253RRRAVsMDNSNAKT_groupRegPhos
S299SPTSRsSDELDPhosphoSitePlus; HPRD; phosphoELM
S399ITLPPsQPSPTPhosphoSitePlus
S315RSRTNsNASTVPhosphoSitePlus
S551GSRALsNSVSNPhosphoSitePlus
S626ECDMEsIIRSEPhosphoSitePlus
S12SPAPLsPLEVEPhosphoSitePlus; HPRD
T395LLDNItLPPSQPhosphoSitePlus
S644DFNFDsLISTQPhosphoSitePlus
T32RPRSCtWPLQRAKT1(PKB) RegPhos
S253RRRAVsMDNSNAKT1(PKB) RegPhos
T32RPRSCtWPLQRSGK1HPRD; RegPhos
T32RPRSCtWPLQRSGK_groupphosphoELM; RegPhos
S644DFNFDsLISTQIKK_betaphosphoELM
S284ESADDsPSQLSPhosphoSitePlus; HPRD; phosphoELM
T179PDKRLtLSQIYFork_headPhosphoSitePlus
S321NASTVsGRLSPPhosphoSitePlus; phosphoELM; RegPhos
S7AEAPAsPAPLSPhosphoSitePlus
T32RPRSCtWPLQRPhosphoSitePlus
T32RPRSCtWPLQRAKT_groupRegPhos
T427GLGSPtSSFNSPhosphoSitePlus; phosphoELM
S253RRRAVsMDNSNPKB_groupphosphoELM
S644DFNFDsLISTQIKKb(IKK betaRegPhos
S315RSRTNsNASTVSGK_groupphosphoELM; RegPhos
S413MQRSSsFPYTTPhosphoSitePlus
S297PGSPTsRSSDEPhosphoSitePlus
S215IRHNLsLHSRFFork_headPhosphoSitePlus
S253RRRAVsMDNSNSGK_groupphosphoELM; RegPhos
S253RRRAVsMDNSNFork_headPhosphoSitePlus
S344DDAPLsPMLYSPhosphoSitePlus
S439VFGPSsLNSLRPhosphoSitePlus
T32RPRSCtWPLQRAKT1HPRD; RegPhos
S26EFEPQsRPRSCHPRD
Y162WGNLSyADLITFork_headPhosphoSitePlus
S253RRRAVsMDNSNSGK1HPRD; RegPhos
T296WPGSPtSRSSDPhosphoSitePlus
S425GSGLGsPTSSFPhosphoSitePlus

Dephosphorylation site
FOXO3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000385824R248WCOSMICHead and Neck Cancer21984974
ENSP00000385824A6SDing2008, COSMICLung Cancer18948947
ENSP00000339527R248WCOSMICHead and Neck Cancer21984974
ENSP00000385824S318CDing2008, COSMICLung Cancer18948947
ENSP00000339527R323HCOSMICHead and Neck Cancer21798893
ENSP00000385824R323HCOSMICHead and Neck Cancer21798893
ENSP00000339527S318CDing2008, COSMICLung Cancer18948947
ENSP00000339527M387ICOSMICOvarian Cancer21720365
ENSP00000385824G86RCOSMICCentral Nervous System Neoplasms18772890
ENSP00000339527G86RCOSMICCentral Nervous System Neoplasms18772890
ENSP00000339527A6SDing2008, COSMICLung Cancer18948947
ENSP00000385824M387ICOSMICOvarian Cancer21720365

Differential expressed protein
FOXO3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FOXO3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STK4_HUMANFOXO3_HUMANkinase -> substrateRegPhos
IKKB_HUMANFOXO3_HUMANkinase -> substrateRobert H Newman (2013)
SGK1_HUMANFOXO3_HUMANkinase -> substrateRegPhos
AKT1_HUMANFOXO3_HUMANkinase -> substrateRegPhos; NetPath
ZAGL2_HUMANFOXO3_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05223Non-small cell lung cancer
hsa05213Endometrial cancer
hsa04722Neurotrophin signaling pathway
hsa04062Chemokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008286insulin receptor signaling pathwayIBAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0007389pattern specification processIBAbiological_process
GO:0045648positive regulation of erythrocyte differentiationIDAbiological_process
GO:0009888tissue developmentIBAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0006950response to stressIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0008301DNA binding, bendingIBAmolecular_function
GO:0003690double-stranded DNA bindingIBAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0042127regulation of cell proliferationIBAbiological_process
GO:0005667transcription factor complexIBAcellular_component
GO:0008134transcription factor bindingIBAmolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0001556oocyte maturationIEAbiological_process
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIBAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0006417regulation of translationIDAbiological_process
GO:0001542ovulation from ovarian follicleIEAbiological_process
GO:0051090regulation of sequence-specific DNA binding transcIBAbiological_process
GO:0042593glucose homeostasisIEAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:0030330DNA damage response, signal transduction by p53 clIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0003677DNA bindingIDAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIMPbiological_process
GO:0005634nucleusIEAcellular_component
GO:0009790embryo developmentIBAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006974response to DNA damage stimulusIBAbiological_process
GO:0006915apoptotic processIDAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0001547antral ovarian follicle growthIEAbiological_process
GO:0001544initiation of primordial ovarian follicle growthIEAbiological_process


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