Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FLNA_HUMAN
Description:filamin A, alpha [Source:HGNC Symbol;Acc:3754]
Location:chrX q28
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y2618LYSVSyLLKDKFilaminPhosphoSitePlus
T1603DNHDGtYTVAYFilaminPhosphoSitePlus
Y506ADFKVyTKGAGFilaminPhosphoSitePlus
Y403ANKTTyFEIFTFilaminPhosphoSitePlus
S1546PTHDAsKVKASFilaminPhosphoSitePlus
T2062LHEGHtFEPAEFilaminPhosphoSitePlus
S1449DVTDAsKVKCSFilaminPhosphoSitePlus
S968VAVSPsLDLSKFilaminPhosphoSitePlus
S2053SRVRVsGQGLHFilaminPhosphoSitePlus
S2414THIPGsPFKIRphosphoELM
T1286DARALtQTGGPFilaminPhosphoSitePlus
Y2642IPGSPyRVVVPFilaminPhosphoSitePlus
T1446PVHDVtDASKVFilaminPhosphoSitePlus
S2163SHCDLsLKIPEFilaminPhosphoSitePlus
Y2305QEPGDyEVSVKFilaminPhosphoSitePlus
S11SRAGQsAAGAAPhosphoSitePlus; HPRD
T915QFSGLtKGDAVFilaminPhosphoSitePlus
S1459SGPGLsPGMVRFilaminPhosphoSitePlus; SysPTM
S1338VTYDGsPVPSSHPRD; phosphoELM
S564QNIGRsPFEVKHPRD
Y287KKARAyGPGIEFilaminPhosphoSitePlus
S2024GQHVAsSPIPVHPRD
T507DFKVYtKGAGSFilaminPhosphoSitePlus
Y2505KYGGPyHIGGSFilaminPhosphoSitePlus
T1334HSVDVtYDGSPHPRD; phosphoELM
T1605HDGTYtVAYVPFilaminPhosphoSitePlus
Y2483ECPEGyRVTYTFilaminPhosphoSitePlus
Y373SPFEVyVDKSQPhosphoSitePlus; HPRD; phosphoELM
Y319GEVLVyVEDPAFilaminPhosphoSitePlus
S1630DEIPFsPYRVRFilaminPhosphoSitePlus
S1436HQVPGsPFKVPHPRD
S1938QHVPGsPFTARHPRD
T2197EGENHtYCIRFFilaminPhosphoSitePlus
Y2379ALEECyVTEIDFilaminPhosphoSitePlus
Y1047EVEVTyDGVPVFilaminPhosphoSitePlus
S1055VPVPGsPFPLEFilaminPhosphoSitePlus
Y1871GHVTAyGPGLTFilaminPhosphoSitePlus
T2336DARRLtVSSLQFilaminPhosphoSitePlus
T1089SPARFtIDTKGHPRD; RegPhos
S1081GLQGGsAGSPAHPRD; phosphoELM
T2328DARRLtVSSLQHPRD
T790KAHEPtYFTVDFilaminPhosphoSitePlus
S734GTYSCsYVPRKFilaminPhosphoSitePlus
S512TKGAGsGELKVFilaminPhosphoSitePlus
S1533EEVPRsPFKVKFilaminPhosphoSitePlus
S2276SKAEIsFEDRKHPRD
Y2388IDQDKyAVRFIphosphoELM
T2381EECYVtEIDQDFilaminPhosphoSitePlus
S2523GPRLVsNHSLHCaM-KII_groupphosphoELM
Y1308NLTETyVQDRGFilaminPhosphoSitePlus
S2053SRVRVsGQGLHphosphoELM
S2152RRRAPsVANVGphosphoELM; RegPhos
S2150VANVGsHCDLSHPRD
S757VSIPNsPFRVNHPRD
S2338RRLTVsSLQESFilaminPhosphoSitePlus
S377VYVDKsQGDASPhosphoSitePlus
S2128QHVPGsPFSVKFilaminPhosphoSitePlus
Y735TYSCSyVPRKPFilaminPhosphoSitePlus
S2155SHCDLsLKIPEHPRD
S1734EHVPNsPFQVTFilaminPhosphoSitePlus
S368QHIAKsPFEVYFilaminPhosphoSitePlus
S3___MSsSHSRAPhosphoSitePlus
S1946QHVPGsPFTARFilaminPhosphoSitePlus
T1762LAPQYtYAQGGPhosphoSitePlus
S2335SSLQEsGLKVNHPRD
T2135FSVKVtGEGRVPhosphoSitePlus
Y731NGNGTySCSYVFilaminPhosphoSitePlus
S2284SKAEIsFEDRKRegPhos
Y1047EVEVTyDGVPVHPRD; phosphoELM; RegPhos
S2406THIPGsPFKIRHPRD
S1343SPVPSsPFQVPFilaminPhosphoSitePlus
T23GGGVDtRDAEMPhosphoSitePlus; HPRD
S1338VTYDGsPVPSSFilaminPhosphoSitePlus
S1459SGPGLsPGMVRHPRD; phosphoELM; RegPhos; SysPTM
Y1862QFYVDyVNCGHFilaminPhosphoSitePlus
S2224QHVPGsPFQFTFilaminPhosphoSitePlus
S2515GPRLVsNHSLHCAMK2GHPRD
S1084GGSAGsPARFTHPRD; phosphoELM; RegPhos; SysPTM
S767NVGAGsHPNKVFilaminPhosphoSitePlus
S2152RRRAPsVANVGPAK1phosphoELM; RegPhos
Y2614VGSRLySVSYLFilaminPhosphoSitePlus
S1343SPVPSsPFQVPHPRD; phosphoELM
S1533EEVPRsPFKVKHPRD; phosphoELM; RegPhos
Y1261SGVQCyGPGIEFilaminPhosphoSitePlus
S753SWGGVsIPNSPFilaminPhosphoSitePlus
Y2388IDQDKyAVRFIFilaminPhosphoSitePlus
S2____MsSSHSRPhosphoSitePlus
S6MSSSHsRAGQSPhosphoSitePlus
S2152RRRAPsVANVGRSK_groupphosphoELM; RegPhos
T333EEAKVtANNDKFilaminPhosphoSitePlus
S4__MSSsHSRAGPhosphoSitePlus
S2152RRRAPsVANVGFilaminPhosphoSitePlus
S2319EHIPDsPFVVPFilaminPhosphoSitePlus
S2292DRKDGsCGVAYFilaminPhosphoSitePlus
Y643QEAGEyAVHVLFilaminPhosphoSitePlus
S2510YHIGGsPFKAKFilaminPhosphoSitePlus
Y1932VLPGDySILVKFilaminPhosphoSitePlus
T782PGVAKtGLKAHFilaminPhosphoSitePlus
S6AGQSHPRD
S1081GLQGGsAGSPAFilaminPhosphoSitePlus
S1436HQVPGsPFKVPFilaminPhosphoSitePlus
T2478EGYRVtYTPMAHPRD
S1470ANLPQsFQVDTFilaminPhosphoSitePlus
S2180TAQVTsPSGKTFilaminPhosphoSitePlus
S2327VVPVAsPSGDAPhosphoSitePlus; phosphoELM; RegPhos
T1307GNLTEtYVQDRFilaminPhosphoSitePlus
S4SRAGHPRD
Y1938SILVKyNEQHVFilaminPhosphoSitePlus
Y1632IPFSPyRVRAVFilaminPhosphoSitePlus
S2414THIPGsPFKIRFilaminPhosphoSitePlus
S2523GPRLVsNHSLHPhosphoSitePlus
T1739SPFQVtALAGDPhosphoSitePlus
Y775NKVKVyGPGVAFilaminPhosphoSitePlus
S2523GPRLVsNHSLHCaMK2gRegPhos
S732GNGTYsCSYVPFilaminPhosphoSitePlus
S2144RRRAPsVANVGHPRD
S2120QHVPGsPFSVKHPRD
Y2400RENGVyLIDVKFilaminPhosphoSitePlus
T1286DARALtQTGGPRegPhos
Y2198GENHTyCIRFVFilaminPhosphoSitePlus
S2330RRLTVsSLQESHPRD
S966FSVAVsPSLDLPhosphoSitePlus; HPRD
S2510YHIGGsPFKAKphosphoELM
S2162KIPEIsIQDMTHPRD
S1476FQVDTsKAGVAFilaminPhosphoSitePlus
S912LDVQFsGLTKGFilaminPhosphoSitePlus
T730DNGNGtYSCSYFilaminPhosphoSitePlus
S1454SKVKCsGPGLSFilaminPhosphoSitePlus
S3HSRAHPRD
S1630DEIPFsPYRVRHPRD; phosphoELM
T69IANLQtDLSDGCHPhosphoSitePlus
S860QATPTsPIRVKFilaminPhosphoSitePlus
S2502YHIGGsPFKAKHPRD
S2128QHVPGsPFSVKphosphoELM
T1594GKPKKtHIQDNFilaminPhosphoSitePlus
Y1763APQYTyAQGGQPhosphoSitePlus
S2158VANVGsHCDLSFilaminPhosphoSitePlus; SysPTM
S1726EHVPNsPFQVTHPRD
T1334HSVDVtYDGSPFilaminPhosphoSitePlus
Y538LGDGVyGFEYYFilaminPhosphoSitePlus
T500VRVKEtADFKVFilaminPhosphoSitePlus
S2284SKAEIsFEDRKFilaminPhosphoSitePlus
T1288RALTQtGGPHVHPRD
S2370DAKVHsPSGALFilaminPhosphoSitePlus
T793EPTYFtVDCAEFilaminPhosphoSitePlus
T2599VHGPRtPCEEIFilaminPhosphoSitePlus
S757VSIPNsPFRVNFilaminPhosphoSitePlus
T1475SFQVDtSKAGVFilaminPhosphoSitePlus
T1377KPNKFtVETRGFilaminPhosphoSitePlus
Y1604NHDGTyTVAYVFilaminPhosphoSitePlus
S72LQTDLsDGLRLCHPhosphoSitePlus
S2SHSRHPRD
S2321PVASPsGDARRHPRD
S2025QHVASsPIPVVHPRD
T31AEMPAtEKDLAPhosphoSitePlus; HPRD
S1084GGSAGsPARFTFilaminPhosphoSitePlus; SysPTM
S2372KVHSPsGALEEFilaminPhosphoSitePlus
S2158VANVGsHCDLSphosphoELM; SysPTM
S2319VVPVAsPSGDAHPRD
Y2380IDQDKyAVRFIHPRD
S2045SRVRVsGQGLHHPRD
S2088SIEGPsKVDINFilaminPhosphoSitePlus
S2123PGSPFsVKVTGHPRD
Y791AHEPTyFTVDCFilaminPhosphoSitePlus
S382SQGDAsKVTAQFilaminPhosphoSitePlus
S2523GPRLVsNHSLHCaMK2_groupRegPhos
Y2479GYRVTyTPMAPHPRD
Y1761QLAPQyTYAQGPhosphoSitePlus
Y1720PQPGKyVICVRFilaminPhosphoSitePlus
Y1604NHDGTyTVAYVHPRD; phosphoELM
Y1525SISVLyGDEEVHPRD

Dephosphorylation site
FLNA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358866E2313*COSMICHead and Neck Cancer21798893
ENSP00000358866T938MCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000358866Hepatocellular CarcinomaNormal vs. Cancercell lineUp4.118646787
ENSP00000358866Gastric CancerMetastasiscell lineUp1.417022644
ENSP00000358866Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000358866Esophageal CancerNormal vs. CancertissueDown0.2519142970
ENSP00000358866Esophageal CancerNormal vs. CancertissueDown0.2719142970
ENSP00000358866Esophageal CancerNormal vs. CancertissueDown0.2919142970
ENSP00000358866Esophageal CancerNormal vs. CancertissueDown0.3119142970
ENSP00000358866Oral CancerNormal vs. CancertissueUp2.919297561
ENSP00000358866Breast CancerNormal vs. CancertissueUp18257521
ENSP00000358866Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000358866Gastric CancerMetastasiscell lineUp1.417022644
ENSP00000358866Breast CancerNormal vs. CancertissueUp2.520005186
ENSP00000358866Breast CancerNormal vs. CancertissueUp5.820005186
ENSP00000358866Breast CancerNormal vs. Cancercell lineDown0.2120543960
ENSP00000358866Breast CancerNormal vs. Cancercell lineDown0.1620543960
ENSP00000358866Breast CancerNormal vs. Cancercell lineDown0.1720543960
ENSP00000358866Breast CancerNormal vs. CancertissueDown0.4820739354
ENSP00000358866Ovarian CancerMetastasiscell lineDown0.3617892554
ENSP00000358866Pancreatic CancerNormal vs. CancertissueUp415526344
ENSP00000358866Pancreatic CancerNormal vs. CancertissueUp2.916230073
ENSP00000358866Gastric CancerTreatment (none vs. drug-resistant)cell lineUp1.420625496
ENSP00000358866Pancreatic CancerNormal vs. CancertissueUp62019199705

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y2388FilaminTEIDQDKyAVRFIPRcholangiocellular carcinoma21253578PhosphoSitePlus
Y1604FilaminQDNHDGTyTVAYVPDcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
PKN1_HUMANFLNA_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANFLNA_HUMANkinase -> substrateRegPhos
KCC2G_HUMANFLNA_HUMANkinase -> substrateHPRD
KCC4_HUMANFLNA_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04510Focal adhesion
hsa04010MAPK signaling pathway
hsa05132Salmonella infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042993positive regulation of transcription factor importIMPbiological_process
GO:0015629actin cytoskeletonIDAcellular_component
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0007596blood coagulationTASbiological_process
GO:0034394protein localization to cell surfaceIDAbiological_process
GO:0045184establishment of protein localizationIDAbiological_process
GO:0051015actin filament bindingIDAmolecular_function
GO:0045022early endosome to late endosome transportIEAbiological_process
GO:0048365Rac GTPase bindingIDAmolecular_function
GO:0004871signal transducer activityIMPmolecular_function
GO:0005576extracellular regionTAScellular_component
GO:0005829cytosolTAScellular_component
GO:0030168platelet activationTASbiological_process
GO:0051220cytoplasmic sequestering of proteinIMPbiological_process
GO:0017048Rho GTPase bindingIDAmolecular_function
GO:0005938cell cortexIEAcellular_component
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0005802trans-Golgi networkIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0050821protein stabilizationIMPbiological_process
GO:0042384cilium assemblyIMPbiological_process
GO:0005080protein kinase C bindingIEAmolecular_function
GO:0034329cell junction assemblyTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIMPbiological_process
GO:0043113receptor clusteringIDAbiological_process
GO:0001948glycoprotein bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0031532actin cytoskeleton reorganizationIDAbiological_process
GO:0031523Myb complexIDAcellular_component
GO:0001837epithelial to mesenchymal transitionIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0031267small GTPase bindingIDAmolecular_function
GO:0051764actin crosslink formationIDAbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0042177negative regulation of protein catabolic processIMPbiological_process
GO:0017160Ral GTPase bindingIDAmolecular_function
GO:0090307spindle assembly involved in mitosisIDAbiological_process
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0007195adenylate cyclase-inhibiting dopamine receptor sigIMPbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0043433negative regulation of sequence-specific DNA bindiIDAbiological_process
GO:0034988Fc-gamma receptor I complex bindingIDAmolecular_function